Caltech Professor Receives “High-Risk, High-Reward” Research Award

first_imgHerbeautyRemove Belly Fat Without Going Under The KnifeHerbeautyHerbeautyHerbeautyThese Are 15 Great Style Tips From Asian WomenHerbeautyHerbeautyHerbeautyWhat Is It That Actually Makes French Women So Admirable?HerbeautyHerbeautyHerbeautyThese Lipsticks Are Designed To Make Your Teeth Appear Whiter!HerbeautyHerbeautyHerbeautyKate Beckinsale Was Shamed For Being “Too Old” To Wear A BikiniHerbeautyHerbeautyHerbeautyCostume That Makes Actresses Beneath Practically UnrecognizableHerbeautyHerbeauty Pasadena Will Allow Vaccinated People to Go Without Masks in Most Settings Starting on Tuesday First Heatwave Expected Next Week More Cool Stuff Top of the News Get our daily Pasadena newspaper in your email box. Free.Get all the latest Pasadena news, more than 10 fresh stories daily, 7 days a week at 7 a.m. Your email address will not be published. Required fields are marked * EVENTS & ENTERTAINMENT | FOOD & DRINK | THE ARTS | REAL ESTATE | HOME & GARDEN | WELLNESS | SOCIAL SCENE | GETAWAYS | PARENTS & KIDS Make a comment faithfernandez More » ShareTweetShare on Google+Pin on PinterestSend with WhatsApp,Virtual Schools PasadenaHomes Solve Community/Gov/Pub SafetyCitizen Service CenterPASADENA EVENTS & ACTIVITIES CALENDARClick here for Movie Showtimes Community Newscenter_img Business News Science and Technology Caltech Professor Receives “High-Risk, High-Reward” Research Award From Caltech.edu Published on Thursday, October 6, 2016 | 11:17 am Henry Lester Credit: Courtesy of H. LesterHenry Lester, Bren Professor of Biology and Biological Engineering, has received a Transformative Research Award from the National Institutes of Health (NIH) as part of the NIH’s High-Risk, High-Reward Research (HRHR) program. The Transformative Research Award, established in 2009 and awarded this year to 12 scientists, supports “exceptionally innovative, unconventional, paradigm-shifting research projects that are inherently risky and untested,” according to the NIH press release.Since he arrived in 1973, Lester has spent his entire professorial career at Caltech. His research now focuses on the actions of drugs on the ion channels, receptors, and transporters of “excitable cells”—cells such as neurons and muscle fibers that use electrical signals. Lester helped to pioneer “inside-out” neuropharmacology, which studies how the interaction of nicotine and nicotine receptors in an organelle called the endoplasmic reticulum leads to the addictive effects of nicotine, and in some cases to neuroprotective effects.With this award, Lester will study the mechanisms by which certain psychiatric drugs exert their therapeutic effects, as well as how additional addictive drugs such as opioids work. He hypothesizes that these drugs also work “inside-out,” binding first to molecular targets within organelles in cells. He and his group aim to develop genetically encoded fluorescent biosensors to measure drugs within organelles.“Nicotine has served as a model for neuroscience and pharmacology ever since Columbus’s crew sampled tobacco,” says Lester. “Caltech continues to support our work on the hypothesis that insights from nicotine help to explain psychiatric and addictive drugs, and this grant provides both additional validation and much-needed support.”Lester has more than 330 publications and nine US patents. He has served as chair of the Caltech faculty and as president of the Biophysical Society. He participates on the California Council for Science and Technology.This year, the HRHR Program, supported by the NIH’s Common Fund, awarded 88 grants in four categories: 12 Pioneer awards, 48 New Innovator awards, 12 Transformative Research awards, and 16 Early Independence awards. Name (required)  Mail (required) (not be published)  Website  Community News Pasadena’s ‘626 Day’ Aims to Celebrate City, Boost Local Economy Subscribe Home of the Week: Unique Pasadena Home Located on Madeline Drive, Pasadena 2 recommended0 commentsShareShareTweetSharePin it last_img read more

Duterte, IATF to decide on ECQ extension today

first_img“For example po, sa Zamboanga, dati GCQ sila. Ngunit noong nag-request ang city government na gawing ECQ, nakinig naman po ang IATF. Ganun din sa Albay, dati dinowngrade na sila sa GCQ but they requested for an extension,” he added. The Metro Manila Council (MMC) is set to recommend before the IATF-EID today three scenarios after the second ECQ extension—first, ECQ extension for at least 15 days, second is to move Metro Manila to GCQ and third is modified combination of an ECQ and a GCQ. “Ginagalang natin ang rekomendasyon ng ating Metro Manila mayors kasi nga po katuwang natin sila sa pagpapatupad ng enhanced community quarantine,” Malaya said in an interview with DZBB. A woman eats her meal beside a sign asking for food, medical supplies, alcohol, and face masks for the poor at a slum area in Quezon City, Manila. The government will decide today whether to extend the enhanced community quarantine in various parts of the country beyond May 15. AARON FAVILLA/AP “Sa Lunes po magkakaron ng approval ang ating Presidente kung anong mangyayari sa atin ng May 15,” Roque said during the Laging Handa virtual press conference over the weekend. The ECQ was first declared on March 17 covering the entire Luzon, to prevent the further spread of COVID-19. It has been extended in several areas, including Metro Manila, twice or until May 15./PNcenter_img MANILA – President Rodrigo Duterte will decide today whether to extend the enhanced community quarantine (ECQ) in some parts of the country, including National Capital Region, beyond May 15. Presidential spokesperson Harry Roque said Duterte will make the verdict during the scheduled Inter-Agency Task Force for the Management of the Emerging Infectious Disease (IATF-EID) this afternoon. Department of the Interior and Local Government (DILG) Undersecretary Jonathan Malaya, meanwhile, said that the IATF-EID will strong consider the recommendation of the MMC. “‘Yan po ay ibabase natin sa siyensiya titignan ang dami ng kaso ng (coronavirus disease 2019) COVID sa isang siyudad sa isang barangay at titignan natin ang kapasidad na magbigay ng critical care,” he added.last_img read more

Woman didn’t know she was pregnant until she had a baby in the bathroom

first_imgA woman in Delaware says she was unaware that she was pregnant until she gave birth to a baby in her sister’s bathroom.The incident occurred last month in Wilmington.Carla Collazo told reporters that she was using her sister’s bathroom when she suddenly began to have severe back pain. She then called out to her sister for help. At some point during the ordeal, Collazo told her sister to open her legs to see what was happening, and that’s when the sisters found out the Collazo was in the process of giving birth.The sisters successfully managed to birth the baby and then called 911 to administer much needed care to both mother and baby.Doctors said despite the baby being born six weeks early and weighing under 3 pounds, the baby is healthy and is recovering in the hospital.The new mother says the whole thing came as a complete shock to her because she did not have any symptoms of pregnancy, had taken several pregnancy test that came back negative, and had previously been told that she may not be able to have children due to a medical condition.Despite the shock, Collazo says she is very happy about her “miracle baby.”last_img read more

A Family Affair at A Steve’s Carpet Cleaning

first_imgFor over 30 years the success of A Steve’s Professional Truck Mounted Steam Cleaning has been a family affair.  Started by Steve Short in 1982, the business now includes the cleaning skills of his son-in-law, Stephen, and office management of his daughter, Rachel.  Steve himself focuses on being the public face of the company but is glad to pick up the overflow—no pun intended—and step in.  As he says, there’s never a need to “turn down a job because within 2-3 days it can be done.”Steve’s granddaughter Alyssa, now almost 7, is a childhood cancer survivor.  Now in remission, the family celebrates her recovery by participating in fundraisers around the region that focus on cures.  Over the past few years they have participated in the CureSearch Walk for Children’s Cancer in Tacoma, and other events, as well as hosting a Facebook referral promotion where every new ‘like’ equals a cash donation to the Mary Bridge Children’s Foundation.Also available on the business website is the autobiography of Steve’s father, Jim.  A celebrated military pilot, the book highlights a storied career in the skies.  As Jim Short writes in the introduction, “Everyone has heard and seen movies about airline pilots as well as fighter and bomber pilots, but I can’t recall that anyone has described the life of a military transport flyer, which is what I have attempted to do.  Mine is not primarily a war story, but a glimpse into my life as a pilot.  My adventures are sometimes routine and sometimes not so routine…they may not be as hair-raising as bomber and fighter missions, but we did have our thrilling moments during war and peace, and I feel lucky to have been a part of it.”Even the business’s trademark lion-in-a-blue-truck logo sprang from a family Valentine’s Day present.  As Steve delivered it home, so many fellow motorists pointed, smiled, and waved it became something of a mascot and now finds its home on business cards and Facebook profiles alike.A Steve’s Professional Truck Mounted Steam Cleaning can be reached at 360-701-9544. Facebook1Tweet0Pin0last_img read more

Virat Kohli reveals only one more seamer spot up for grabs in 2020 T20…

first_imgAdvertisement 4amNBA Finals | Brooklyn Vs4b61q20Wingsuit rodeo📽Sindre E1p( IG: @_aubreyfisher @imraino ) 3nmWould you ever consider trying this?😱2vgbCan your students do this? 🌚9dxk6vi6Roller skating! Powered by Firework With everyone curious about the 2020 World Cup squad that is to be held in Australia, Indian team captain, Virat Kohli, reveals that there is only one seamer spot left, and plenty of pace bowlers are eyeing the vacant spot. He reveals the players that are being considered at the moment- Jasprit Bumrah, Mohammad Swami, Bhuvneswar Kumar, and Deepak Chahar.Advertisement India had a reputation for having a lot for pace bowlers, which makes the competition tough to be chosen to be a part of the WC team, but Virat considers this positively. He said, “The fight obviously is for one spot, and I think more or less three guys have made a place for themselves. It’s going to be a healthy competition, and it will be interesting to see how it pans out.”Advertisement Deepak Chahar is a new entrant who debuted in the pink-ball Test series against Bangladesh. The bowler had an impressive run at the series. Deepak (Chahar) has come in and has bowled really well,” he told the media. Upon the return of the bowlers Bumrah and Kumar to the T20 International series, Virat is confident that the pace attack will be strong in the upcoming Test match against West Indies.Mohammad Shami becomes third Indian bowler in top 10 of ICC test bowling rankingsAdvertisement No-balls to be called by third umpires in upcoming India-WI series  Advertisementlast_img read more

Summer’s Not Over Yet: Beaches Open, Events Planned

first_imgBy Liz Sheehan |The tourists are mostly gone, but Two River area residents can still savor summer this weekend at fairs, beach events, moonlit walks, tours, and a swim at a lifeguarded beach.The annual Monmouth Beach Firemen’s Fair will be held for its 70th year, according to Mayor Sue Howard. The fair, once held behind the firehouse in the town, has relocated to the parking lot of the Monmouth Beach Bathing Pavilion on Ocean Avenue and will run from Thursday, Sept. 7 through Sunday, Sept. 10, with a fireworks display on Saturday at dusk.The fair will be open from 6 to 11 p.m. on Thursday, Friday and Saturday and 5 to 10 p.m. on Sunday.There will be rides and games for all, as well as lobster dinners, steamers, sausage and pepper sandwiches, hot dogs and hamburgers, and a wine and beer garden. Live entertainment will feature Pam McCoy & Friends on Thursday, West End Dogs on Friday, the Sundries on Saturday and Pez Head on Sunday.On Saturday, Sept. 9, Jersey Shore Skim Camp will host the Sea Bright Skim Bash from 9 a.m. to 5 p.m. on the municipal beach behind Borough Hall. The event is held twice a year in the borough, in June and September. Participants include both professionals and amateurs.There is no fee for spectators, but competitors who register for the event pay $20 for Jersey Shore Skim Camp members, $35 for amateurs, $50 for semi-professionals and $100 for professionals. Sean Stratton, a staff member of the Jersey Shore Skim Camp said the sport is international with participants from countries including the United States, Mexico, Spain and Chile.A little farther north, Gateway National Recreation Area, will hold multiple activities.On Friday, Sept. 8, there will be a Harvest Moon Walk from 7 to 8:30 p.m. beginning at the U.S. Life-Saving Parking Lot between lots D and E. Call 732-872-5970 for reservations.On Saturday from noon to 4 p.m. at the Horseshoe Cove Parking Lot L, there will be guided tours of the Nike Missile Radar Site, a one-time top secret missile site from the Cold War era. Some of the veterans who worked on the Nike system will be there to meet and educate the public. These tours will also be held on Sept. 17, Oct. 7, 15 and 29 and Nov. 4 and 11 at the same time.Lighthouse Tours will continue from 1 to 4:30 p.m. until Oct. 31, while daily tours at History House, Building 1, in Officers Row, a home furnished in WWII-era style will be held from 1 to 5 p.m.Free yoga on the beach will take place every Saturday in September from 9 to 10 a.m. at Lot E Beach.Some beaches will be open with lifeguards this weekend. Monmouth County’s Seven Presidents Oceanfront Park in Long Branch will be fee-free on Sept. 9 and 10. Lifeguards will be at the beach from 8 a.m. to 5 p.m.Sandy Hook will have lifeguards on the beach but not on lifeguard chairs on the weekend, Daphne Yun, acting public affairs officer for the National Parks Service, said Tuesday. Beachgoers are encouraged not to swim, she said, but would not be prevented from doing so.The Monmouth Beach Bathing Pavilion will be open on Sept. 9 and 10 from 10 a.m. to 7 p.m., with a $9 daily fee for those 12 and over for the beach. Lifeguards will be on the beach there until 5:30 p.m.This article was first published in the Sept. 7-14, 2017 print edition of the Two River Times.last_img read more

Ohio Ag Weather and Forecast November 4, 2019

first_imgShare Facebook Twitter Google + LinkedIn Pinterest We start off the week with some nicer weather. Partly to mostly sunny skies are expected today. Tomorrow we have to leave the door open for some hit and miss moisture south of a line from Cleveland to Dayton. However, the moisture is not impressive or well organized, so only a few hundredths to .25″ are truly possible with coverage at no better than 50%. The rest of the day and the rest of the state will feature a mix of clouds and sun. We are dry and at least partly sunny again on Wednesday.Thursday we have a minor disturbance trying to come up from the south. This will bring moisture potential to areas from I-70 southward at a minimum, and we may see it expand farther north through Thursday afternoon. Rain totals can be from ..05″-.4″ with coverage at 80%. The track and northern extent of this system is still up in the air at this time, so this will be something we watch closely over the next day or two.A major push of cold air is on the way behind that system for late in the week. Clouds mix with sun for Friday, and we turn out partly to mostly sunny Saturday and Sunday. Lake effect snows are possible on Friday in NE Ohio, clouds increase Sunday afternoon.Another cold push, this time with moisture attached, comes for Sunday overnight through Monday. This will trigger snow statewide, and the next leg down in a brutal cold push. We expect snow accumulation in most of the state, from a coating to 2 inches. Then we get very cold for Tuesday and Wednesday as skies clear out, except for some lake effect snow along the south shore of Lake Erie.Generally, there are some windows of opportunity for harvest in the next 10 days, as we see mostly minor moisture. The map at right shows 10 day liquid equivalent cumulative moisture. However, the cold air will be advancing fast over the region from late this week through next.last_img read more

Microsoft Completes Journey To Big Data Through Hadoop

first_imgThere’s no beating around this bush. Today Hortonworks announced a new beta version of its Hadoop Data Platform that will run on Microsoft Windows Server, a move that shows Microsoft’s own Big Data efforts will forever be connected to open source innovation. This is a highly significant – even expected – move in the big data sector, but also a very strange one.Hadoop, of course, is an open-source software architecture that supports distributed computation jobs on huge data sets – in other words, classic Big Data work. Hortonworks, meanwhile, is one of the bigger Hadoop vendors in the market, even if that’s more in terms of innovation than sales, where it trails Cloudera. Hortonworks founder and architect Arun Murthy is one of the original Hadoop coders who came out of Yahoo back in the day, and he also serves as the VP of the open source Apache Hadoop project at the Apache Software Foundation.Which all means that any major platform move like this is sure to impact the rest of Hadoop development and, by extension, the rapidly growing Hadoop ecosystem that’s driving much of the big data sector.Why Windows?Until today’s announcement, Hadoop of any flavor typically ran on a Linux-based machine (physical or virtual). This made a lot of sense, since one of the big advantages of Hadoop is the capability to expand its data warehousing over any number of clustered computers. When those clustered machines are running Linux, it’s all but frictionless to add more, both in in terms of licensing cost (which is free) and configuration (which is easy).But when the underlying operating system is Windows Server, licensing – i.e., explicitly not free – would seem likely to create a lot more friction when someone tries to build a Hadoop cluster. Wouldn’t using Windows Server as the OS for a Hadoop system be too expensive?David McJannet, VP of marketing at Hortonworks, doesn’t seem to think so. McJannet’s concern was that too many Windows-based shops out there were shying away from Hadoop because they didn’t want to deal with adding Linux clusters and the related hassle of managing them. So assuaging those concerns was one big reason Microsoft has been working with Hortonworks over the past 18 months.The sheer number of Windows installations was also a major issue. McJannet said that a “majority of servers” were running Windows in the enterprise now. In its press release, Hortonworks cited IDC data thusly: “According to IDC, Windows Server owned 73 percent of the market in 2012 (IDC, Worldwide and Regional Server 2012–2016 Forecast, Doc # 234339, May 2012).”It is not clear just what server class this 73 percent represents, since the report itself costs $4,500, and is thus a little hard to access. File servers? Application servers? It’s sure not web servers, where according to Web analytics from Netcraft, Microsoft currently has 16.93% of the marketshare, dwarfed by Apache’s 55.26% marketshare.McJannet also said Hadoop on Windows would make data exploration easier. Using SQL-based queries that can now directly integrate with the Hadoop Distributed File System (HDFS), products like SQL Server and Excel can tap straight into Hadoop-stored data, enabling end-users to more easily navigate vast stores of data in Hadoop clusters.Embracing Open SourceThis is not Hortonworks’ first foray into Windows land. Late last year, it released the Windows Azure HDInsight product – essentially Hadoop for the Azure cloud platform.As odd as it may seem to see Hadoop on Windows Server, the move makes a lot of sense from Microsoft’s side. The company has needed a Big Data entry ever since it decided to drop its own Dryad data warehousing framework back in 2011. Some observers have expected this day ever since a year ago, when Microsoft announced it would build in tools within SQL Server to connect to Hadoop.McJannet emphasized that to date, Microsoft was playing well with others within the open source development model that Hadoop uses, so much of its innovation will cycle back to the rest of the Hadoop community.If so, you can expect to see more Hadoop vendors to announce their own connections to Windows in the near future.Image courtesy of Shutterstock 3 Areas of Your Business that Need Tech Now Massive Non-Desk Workforce is an Opportunity fo… Related Posts Tags:#Big Data#Hadoop#Microsoft center_img brian proffitt IT + Project Management: A Love Affair Cognitive Automation is the Immediate Future of…last_img read more