Steven Gerrard wants to sign a few more players

first_imgEven after making 10 signings this summer, Rangers boss Steven Gerrard wants “a few” more players, saying “this will be a different team from last year”.The coach say he wants to sign another centre-half during this transfer window to bolster his team’s defence, although he had already signed Connor Goldson from Brighton and Nikola Katic from Croatian side Slaven Belupo.Rangers have had a bid of £200k rejected for Hearts striker Kyle Lafferty, however, Gerrard has refused to be drawn on their interest in the player.“We have tried to add players who are hungry, the idea was to have two quality players in each position,” said Gerrard, according to Sky Sports.Steven Gerrard, Michael OwenOwen reveals why Liverpool didn’t offer Gerrard a new contract Manuel R. Medina – September 6, 2019 According to Owen, the Reds wanted to sell Gerrard two years before he left the club and that’s why they didn’t offer him a contract renewal.“It’s no secret we are still looking to add a few pieces to the jigsaw. This will be a different team from last year.“I can’t speak on last season but the mentality of my players will be there and we will have winners on the pitch and winners on the bench.“We don’t just want numbers, we want quality. We know our targets and who we will go after.”last_img read more

Queiroz says the real Asian Cup starts now

first_imgIran and Iraq tied 0-0 in Matchday 3 of the 2019 AFC Asian Cup, and the Iranian team is now ready for the next stage of the competition.Iran and Iraq tied 0-0 today as the Iranian team ended up on the first place of Group D in the 2019 AFC Asian Cup.And Iran coach Carlos Queiroz has said that the real competition starts now.“I have no energy now. It was so intense, but it was played in good spirits. There was a lot of excitement in both teams,” Queiroz told The Khaleej Times.“We controlled the game. In the first half, we played better. We created two chances. The second half, it was 50-50. At the end of the day, for the commitment and the effort from both teams, I think the draw was a fair result.”Cristiano Ronaldo, PortugalAli Daei wouldn’t be upset if Ronaldo breaks his scoring record Andrew Smyth – September 13, 2019 Iranian legend Ali Daei wouldn’t be upset to lose his record as international football’s all-time record scorer to the “great” Cristiano Ronaldo.“We played a very good game against a very tough team. My players came out with great character,” Queiroz added.“When it’s necessary to play, they play. When it’s necessary to fight, they fight. Now they must be ready to play the game that is in front of them.”“We will try to be mentally fresh for the next game because now the real Asian Cup starts. From now on, only the team that wins will survive,” the Iran coach said.“For us, our goal was to qualify. After the first two games, we felt that we could be top of the group. Another goal was to give the opportunity to some players against Iraq. We made five changes. All of them showed that they are ready to compete.”last_img read more

Benitez amazed by Schars brilliant solo goal

first_imgNewcastle manager Rafa Benitez says he was surprised Fabian Schar’s solo goal in their 3-0 home win against Cardiff City on Saturday.Benitez praised Schar for his moment of individual brilliance after he scored a stunning goal against Cardiff City at St James Park.Schar went on a 40-yard dribble before sending the ball flying into the bottom left corner, leaving Cardiff City goalkeeper Neil Etheridge helpless.The defender also scored in the second half to complete his brace and to double Newcastle’s advantage. Ayoze Perez completed the scoring in stoppage time to make it 3-0.“Not the first one,” Benitez told Sky Sports when asked if he knew Schar had the ability to score such a goal.“You can expect him to score maybe from a corner but he’s a player with quality and he was going forward. It was a great goal.”Premier LeaguePremier League Betting: Match-day 5 Stuart Heath – September 14, 2019 Going into the Premier League’s match-day five with a gap already beginning to form at the top of the league. We will take a…Newcastle United climbed out of the relegation zone after their first win in nine Premier League games, and Benitez was delighted with the result.“We played extra-time in the FA Cup and scored four goals – that gave everyone confidence today,” he said.“We could see from the first minute our team wanted to get three points against a rival. We did really well. Everyone has to be pleased.“My message to the fans was to stay calm and support the team – the players did well and the fans enjoyed every minute.”last_img read more

Craig Gordon remembers the time he broke his arm

first_imgThe Celtic goalkeeper broke his arm while battling for the ball with Jermain Defoe and he was out for three monthsExactly nine years ago, Craig Gordon was Sunderland’s goalkeeper and he got his arm broken after a collision with Tottenham Hotspur Jermain Defoe.“I got to the ball first and he got their second and broke my arm. That was a bad break and I had to get a metal plate inserted in my arm,” Gordon told The Chronicle Live.“I was out for another three months and came back and played the rest of the season with the metal plate.”“That summer I got the metal taken out of my arm and very soon into pre-season the arm broke again and that was another three months when it got put back in again,” he added.Mikey Johnston, CelticJohnston is disappointed after being injured Manuel R. Medina – September 11, 2019 Celtic winger Mikey Johnston was disappointed to miss Scotland Under 21 national team’s victories over San Marino and Croatia, and he hopes he can return to play soon.“That was the third operation on my arm and that was frustrating. The metal plate is still in there today so I have not had any more trouble with it.”“Every time I felt like I was getting to a point where I was putting in good, consistent performances, something else would come up,” he commented.“I was starting to play in games where I probably wasn’t fit and I was starting to think whether this would ever be fixed.”“This was a very long-term thing and perhaps it was something I wouldn’t come back from,” he added.“There had been so many things that had gone wrong I felt I had to leave.”last_img read more

My natural habitat is winning Mourinho

first_imgThe former Manchester United manager believes that people learn more by winning that by losing in the world of football.Portuguese coach Jose Mourinho has always been very charismatic and controversial.And after he was sacked by Manchester United, he started working for TV channel DAZN.“People used to say that you learn more with defeat. Maybe there is some truth in it,” he told The Telegraph.“I feel my natural habitat is winning. This is the first time when I didn’t win any trophy for 18 months. Some guys don’t win any trophies for 18 years. I didn’t win any trophy for 18 months.”“Now I have time for thinking, reflection, trying to understand everything and trying to be more ready for the next one that is coming. I know it is coming. It hasn’t come yet because what has come along, I didn’t want,” he explained.Harry Maguire, Manchester UnitedLiverpool legend Nicol slams Harry Maguire’s Man United form Andrew Smyth – September 14, 2019 Steve Nicol believes Harry Maguire has made some “horrendous mistakes” recently, and has failed to find his best form since joining Manchester United.“I want to work in a club that understands there is a structure in place. I don’t want to work in a structure of no coincidence [unity] in the thinking.”“People sometimes say ‘this manager doesn’t like to work with a football director’; ‘this manager doesn’t like to work with chief scout’; ‘this manager doesn’t like to work with an owner’; ‘this manager doesn’t like to work with the president’,” he commented.“During my career, I have been working in every possible circumstance. The most successful situations are not because of the structure but because of the empathy in the structure.”“People who work well together. People who share the same kind of ideas. This is the fundamental thing,” he added.“You now have a generation of players who are not just players but the whole package. You have the player, the family, the agent, the entourage, the director of communication. You sometimes have the individual’s medical people and in an extreme situation you even have what they call their ‘personal fitness guys’.”“When you have a player you have all these distractions. And if there is no empathy in the structure of the club you get into so many contradictions that it is really, really difficult to work.”last_img read more

Lindsey Buckingham Announces Tour And Solo Anthology

first_img Facebook The GRAMMY-winning songwriter/guitarist will be releasing a greatest hits album and touring North America this fall in supportAna YglesiasGRAMMYs Aug 14, 2018 – 5:39 pm The former Fleetwood Mac guitarist Lindsey Buckingham announced today that he will be releasing Solo Anthology: The Best of Lindsey Buckingham this fall, and touring North America in support of the album. https://twitter.com/LBuckingham/status/1029427791912165377 News Twitter The collection, which will be available Oct. 5 both digitally and as a three-disc set, will include two previously unreleased songs, plus remastered and live versions of Buckingham’s hits spanning his career, from his 1981 solo debut album Law And Order to his 2017 duet album with former-bandmate Christine McVie. A special vinyl version will also be available at a later date.Buckingham began making music with Fleetwood Mac when he and Stevie Nicks joined the band in 1975, helping write many of their hits, including GRAMMY-nominated classic “Go Your Own Way.” Fleetwood Mac, along with Buckingham, was honored as the 2018 MusiCares Person of the Year, the first ever band to receive the award.The tour will begin on Oct. 7 in Portland, Ore., with tickets on sale this week. All tickets purchased will include a copy of the new album; to purchase tickets and for more information, visit Buckingham’s website.Catching Up On Music News Powered By The Recording Academy Just Got Easier. Have A Google Home Device? “Talk To GRAMMYs”Read more Lindsey Buckingham Announces Solo Tour, Anthology lindsey-buckingham-announces-tour-and-solo-anthology Lindsey Buckingham Announces Tour And ‘Solo Anthology’ Email last_img read more

Sonic Temple 2019 Lineup With System Of A Down Lamb Of God

first_img Facebook System Of A Down Reunite For Sonic Temple 2019 sonic-temple-2019-lineup-system-down-lamb-god-more Email https://twitter.com/SonicTempleFest/status/1067059068550828032 Twitter Sonic Temple 2019 Lineup With System Of A Down, Lamb Of God, More News Ohio hosts 2019’s inaugural hard-rock festival experience — its stacked lineup reveals a debut with a pedigreePhilip MerrillGRAMMYs Nov 26, 2018 – 1:51 pm Danny Wimmer Presents has announced the lineup for the Sonic Temple Art & Music Festival to be held in Columbus, Ohio on May 17–19, 2019, including the reunited System Of A Down, plus other GRAMMY winners  Foo Fighters, Ghost, Halestorm, and Tom Morello.While replacing the successful 12-year run of Rock On The Range, Sonic Temple aims to be more than just a festival with expanded art, comedy and food experiences.”Although in its inaugural year, Sonic Temple’s pedigree is proven, and its roots are strong,” said System Of A Down’s Shavo Odadjian. “It made total sense for us to be involved.”That pedigree has also drawn GRAMMY nominees Disturbed, Gojira, Joan Jett And The Blackhearts, Killswitch Engage, Lamb Of God, Mark Lanegan Band, Meshuggah, and The Prodigy. The exciting array of rockers also includes Action Bronson, Beartooth, The Black Dahlia Murder, Bring Me The Horizon, Chevelle, The Cult, Pussy Riot, Yungblud, and many more.The fest’s SiriusXM Comedy & Spoken Word Tent will host, among others, GRAMMY winner Henry Rollins, GRAMMY nominee Andrew Dice Clay and Pauly Shore.Tickets for the inaugural experience go on sale at the Sonic Temple Festival website on Nov. 30 at noon, eastern time.Black Dahlia Murder: For The Love Of Melodic MetalRead morelast_img read more

Raghuram Rajan Criticizes Srikrishna Committee Recommendations Opposes Bringing All Regulators into One

first_imgReserve Bank of India (RBI) governor Raghuram Rajan opposed recommendations in the BN Srikrishna Committee report, and termed merging of all regulators into one entity as “schizophrenic”.The report was submitted in March 2013. Rajan debated regarding the recommendations mentioned in it during an industry event in Mumbai on Tuesday. Financial Sector Legislative Reforms Committee (FSLRC) report is important in the financial history but most of the recommendations are “faddish” and “impressionistic” than scientific, according to Rajan.The RBI governor points out two “fundamental areas of tension” from the report in his speech. One is the size and scope of regulators and the other is the negligence of regulators. Rajan claims the report does not give importance to the magnitude of synergies gained or lost.”It emphasizes synergies in bringing together some regulators into one entity. But in the process it suggests breaking up other regulators, with attendant loss of synergies,” he pointed out.The report suggests that laws which do not micromanage, gives regulators the freedom to fill in the details, in accordance with the changing needs of the economy.Speaking of this suggestion, Rajan stated: “At the same time, the FSLRC wants to check and balance the activities of regulators through judicial oversight. Too much of checks and balances could completely vitiate the flexibility afforded by rewriting laws.”Rajan opposed the recommendation mentioned in the report that merging of all regulation of trading will be done under one roof and consumer protection regulation under another. According to him, if it is implemented, then it will slow down the consistency and development of the market.The RBI governor said if the government wants to manage its own debt, then the RBI will not come in its way.”I don’t believe the government suffers any less from conflicts of interest in debt management (unlike the views of the FSLRC), but the RBI could well carry out the government’s instructions without any loss in welfare,” he said.Rajan was not in favor of implementing such recommendations as according to him, if something is not broken, there is no need to fix it.”As the Chinese would say, let us recognize the value of crossing the river by feeling each stone before we put our weight on it. Let us not take a blind jump hoping that a stone will be there to support us when we land. Or in American, if it ain’t broke, don’t fix it!” he said.last_img read more

Dear Comrade box office collection in USA premieres Vijay film beats F3

first_img2NTR Kathanayakudu$482,599 8Jersey$144,687 3Dear Comrade$273,000 1Maharshi$516,441 2Mahanati$303,456 7Oh Baby$148,589 5NOTA$128,760 1Geetha Govindam$377,930 4F2 – Fun and Frustration$259,433 RankMovieCollection RankMovieCollectioncenter_img 3Dear Comrade$273,000 4Arjun Reddy$194,051 Dear ComradeTwitterVijay Devarakonda-Rashmika Mandanna’s Dear Comrade started with a bang and made a superb collection at the USA box office in the premiere shows. It has beaten the record of F3 – Fun and Frustration and become the third biggest opener of 2019 in the country.Geetha Govindam is a blockbuster at the USA box office and the sparkling chemistry between Vijay Devarakonda and Rashmika Mandanna is one of the biggest factors, which contributed to its huge success. The hit couple is back together with Dear Comrade and their presence created a lot of hype. Besides the film is simultaneously released in Telugu, Tamil, Malayalam and Kannada languages.Hence there was a huge demand for the overseas theatrical rights of Dear Comrade and several leading distribution houses were vying their hands for its rights. But Sarigama Cinemas clinched them for a whopping price of Rs 3.50 and planned to release it in over 220 screens across the USA, the UK, the UAE, Australia and other foreign markets in a bid to cash on huge hype surrounding the movie.The hype helped Dear Comrade to make a good advance booking for its opening weekend with its pre-sale business crossing 250,000 hours before its preview shows began. The distributors held a large number of premiere shows across the USA on Thursday, a day before its release in India. The movie witnessed massive response in all the cinema halls and some centres ran to packed houses.The distributors are yet to reveal their business details. If we are to go by early trends, Dear Comrade has collected $273,000 at the USA box office in the premiere shows. A film critic with Twitter handle @benny_speaks tweeted, “#DearComrade USA premiere Gross at 8 PM: $273,000 from 172 locations @TheDeverakonda @MythriOfficial @iamRashmika @bharatkamma.”When the final figures are revealed, Dear Comrade will easily cross $300,000 mark at the USA box office in the premiere shows. The movie has beaten the records of Arjun Reddy, Nota and Taxiwaala and become the third biggest opener for Vijay Devarakonda after Mahanati and Geetha Govindam.Here are Vijay Devarakonda’s top five biggest openers at the USA box office.RankRankMovieMovieCollectionCollectionRank1MovieGeetha GovindamCollection$377,930Rank2MovieMahanatiCollection$303,456Rank3MovieDear ComradeCollection$273,000Rank4MovieArjun ReddyCollection$194,051Rank5MovieNOTACollection$128,760Rank6MovieTaxiwaalaCollection$94,270 5Vinaya Vidheya Rama$181,118 6Majili$162,542 6Taxiwaala$94,270 9NTR Mahanayakudu$102,234 If we are to go by the early trends, Dear Comrade has already beaten the opening records of Varun Tej’s F2 – Fun and Frustration and Ram Charan’s Vinaya Vidheya Rama at the USA box office. It has become the third biggest opener of the year. Here is the list of top 10 biggest opener Telugu Movies in USA – 2019.RankRankMovieMovieCollectionCollectionRank1MovieMaharshiCollection$516,441Rank2MovieNTR KathanayakuduCollection$482,599Rank3MovieDear ComradeCollection$273,000Rank4MovieF2 – Fun and FrustrationCollection$259,433Rank5MovieVinaya Vidheya RamaCollection$181,118Rank6MovieMajiliCollection$162,542Rank7MovieOh BabyCollection$148,589Rank8MovieJerseyCollection$144,687Rank9MovieNTR MahanayakuduCollection$102,234Rank10MovieLakshmi’s NTRCollection$90,770 10Lakshmi’s NTR$90,770last_img read more

Managing complexity Novel protein folding tool vastly simplifies understanding how sequence encodes

first_img Citation: Managing complexity: Novel protein folding tool vastly simplifies understanding how sequence encodes structure (2016, November 29) retrieved 18 August 2019 from https://phys.org/news/2016-11-complexity-protein-tool-vastly-sequence.html (Phys.org)—Protein folding is the process by which a polypeptide (a linear organic polymer chain consisting of many amino acid residues, or monomers) transforms from a random coil into the 3D conformation in which it can perform its biological function. Since different proteins fold into a range of very different shapes, the Protein Data Bank (PDB) – a database archive comprising experimentally-determined three-dimensional structures of large biological molecules, including numerous protein conformations – can be disarmingly complex. This is problematic because that space is fundamental to understanding how sequence encodes structure. Recently, however, scientists at Dartmouth College deconstructed the universe of known protein structures into reusable building blocks that they term tertiary structural motifs, or TERMs. (Structural motifs are compact blocks of a 3D protein structure.) They found that 50% of PDB protein conformations were described – at sub-Angstrom resolution – by a surprisingly small group of roughly 600 TERMs. Moreover, TERMs allowed them to discern sequence–structure relationships. The researchers state that these results can be used for protein structure prediction, protein design and other applications. In addition, some 600 TERMs describe 50% of the known protein structural universe at sub-Angstrom resolution. “This refers to the level of degeneracy we discovered in the protein structure space.” That only ~600 TERMs are required to describe half of all residues and inter-residue contacts in known protein structures suggests that at the local structural level, there just are not that many structural patterns that naturally emerge. There are, of course, a large number of more rare geometries, and full coverage of the protein structural universe requires tens or even hundreds of thousands of TERMs – but nevertheless, the majority of protein structure does appear to be quite degenerate at the local level.”As to the specific implications of their study for protein structure prediction, protein design, and other applications, Grigoryan points out that the major implication for protein design and structure prediction is the novel means of mining for sequence-structure relationships. “Statistical potentials, derived from known protein structures, have been employed for decades in both of these applications. However, such potentials typically describe the statistics associated with isolated simplistic structural features, like dihedral angles, individual interatomic or interresidue distances, or burial environments. However, TERMs offer the potential to describe sequence statistics in the context of holistic structural environments, which would be much more useful for both design and prediction.” Specifically, he explains, in design, this would allow for a better understanding of what sequences would or would not form the target structure; for prediction, it would help drive structural sampling towards structures whose TERMs are most consistent with the modeled structure. “A potential limitation is the amount of available data, because not all TERMs have sufficient known instances to synthesize accurate sequence models,” he acknowledges. “However, the early results shown in our paper, as well as some unpublished results in our lab, point to the fact that TERM-based statistics are already providing non-trivial insights that in many cases, other methods are unable to easily capture – and this is only going to get better as the amount of structural data continues to accumulate.”When asked about the implications of their work for synthetic genomics and synthetic proteomics, Grigoryan said “It’s a good question. I can certainly see a future in which a truly robust method for computational protein design serves as a key element in synthetic genomics and proteomics applications. I’d say that in terms of our current design techniques, we’re not quite there today – but our goal with TERM-based and other developments – as well as the general goal of our field – is certainly to keep improving the robustness of our methods, so that one day, we can offer them as black-box solutions to folks in other disciplines, whether that be materials science, biomedicine, or synthetic biology.”Moving forward, Grigoryan says that the team is focused on extending the capabilities of their TERM-based techniques to both protein design and structure prediction. “We’re also very interested in introducing ensemble-based modeling approaches into protein design: Since protein structural states are really conformational ensembles, the language of statistical mechanics is most appropriate for describing their behavior. Therefore, we’re pursuing methods for introducing statistical mechanics-based calculations towards improving the accuracy and robustness of protein design methods.”In addition to protein design and structure prediction, Grigoryan sees their study as having strong implications for our fundamental understanding of protein structure in general. “I think the new look at the protein structural universe our study offers can help not only with modeling and designing proteins, but it can also help with teaching about protein structure. The ideas of modularity and representation of standard motifs,” he concludes, “have already made their way into my own teaching here at Dartmouth.” Fig. 1. Discovering TERMs that optimally describe the protein structural universe. (A) A candidate motif is defined around each residue in the database, structural matches (from within the database) to each motif are identified using MASTER (58), and these matches are used in defining the coverage of every motif. Next, the set cover problem is solved to find the minimal set of motifs that jointly cover the structural universe. (B) Coverage of the universe as a function of the number of TERMs, in the order discovered by the greedy algorithm (inset uses logarithmic scale along the x axis). Mackenzie CO, Zhou J, Grigoryan G (2016} Tertiary alphabet for the observable protein structural universe. Proc Natl Acad Sci USA 113(47):E7438-E7447. Fig. 2. Universal TERMs. (A) Top 24 TERMs ranked by the number of elements covered in the set cover procedure; jointly these cover roughly a third of the universe elements. (B) A diverse selection of high-priority TERMs that span from one- to five-segment motifs, shown in the first to fifth columns, respectively. Shown in each column are representatives from the three most common secondary-structure classes for the given number of segments (SI Appendix, SI Methods). In both A and B, each TERM is represented with ten randomly chosen matches along with its centroid. The text underneath each TERM is formatted as follows: r; n (s/c) where r is the rank of the TERM in the set cover (lower rank corresponds to higher priority), n is the number of unique matches, s is the total fraction of universe elements covered by the TERM, and c is the marginal fraction of the universe elements covered by the TERM (i.e., fractional coverage of those elements not already covered by preceding TERMs in the set cover). Mackenzie CO, Zhou J, Grigoryan G (2016} Tertiary alphabet for the observable protein structural universe. Proc Natl Acad Sci USA 113(47):E7438-E7447. Grigoryan adds that by using residues and contacts rather than an a priori structural alphabet, defining the motif candidates was much easier. “It seemed particularly natural to define one candidate motif for every residue in the structural database,” he notes, “such that the motif would capture the residue and all of its contacts – that is, the motif would describe that residue’s local structural environment.” More information: Tertiary alphabet for the observable protein structural universe, PNAS November 3, 2016, Published online before print, doi:10.1073/pnas.1607178113 Researchers find possible universal code of protein structure A key finding discussed in the paper was that universal TERMs provide an effective mapping between sequence and structure. “Because universal TERMs recur many times in unrelated proteins,” Grigoryan tells Phys.org, “compiling the list of occurrences of each TERM allows us to start gleaning sequence rules that may underlie each of these structural motifs. The question was whether these sequence rules reflected fundamental determinants of structure, or simply noise from a limited structural database potentially biased by arbitrary evolutionary choices or the selection of proteins whose structures have been solved.” The team resolved this through a series of experiments in which they demonstrated that a significant component of the sequence statistics emerging from TERM matches does likely emerge from fundamental sequence-structure relationships.In effect, the natural utilization of TERMs provides a means of uncovering sequence–structure relationships. “Let’s say a given TERM is consistent of a two-strand beta sheet interacting with an alpha helix at a particular characteristic crossing angle and distance,” Grigoryan illustrates. “If we happen to have, for example, 600 instances of this motif from unrelated proteins, we essentially have 600 different examples of nature having made this structure with different amino-acid sequences. We can then use these 600 sequences to begin to understand what sequence features may be required or preferred to form such a structure – and we can do this for any TERM with sufficiently high usage in nature.”It turns out that by using this approach systematically for all TERMs contained in a given protein backbone structure, sequence variability predicted from TERM data agrees closely with evolutionary variation. “We can deduce a statistical model of what sorts of sequences would be likely to fold to that structure,” he explains. “If we then ask this model to produce a whole bunch of such sequences, we find that the emergent sequence variability is often in close agreement to the evolutionary variability observe for the corresponding protein.” © 2016 Phys.org This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Prof. Gevorg Grigoryan discussed the paper that he and his co-authors published in Proceedings of the National Academy of Science of the United States of America. One of the primary challenges in their study was decomposing the set of known protein structures into standard reusable tertiary structural motifs. “The main challenge here was probably knowing where to begin,” Grigoryan tells Phys.org. “Our overarching goal was to describe, in his words, an alphabet of protein structure.” However, he points out that – unlike with text – the researchers were not able to visually determine where one structural unit (metaphorically a letter) began and another ended. “The number of ways in which we can potentially partition protein structure is extremely large, and so the task of finding a good decomposition seemed overwhelming.”The scientists addressed this problem by not defining a priori what the letters of the structural alphabet should be, but rather defining the task that these letters should accomplish – that is, describing the set of all residues and residue pair contacts observed in known protein structures. Next, they selected the smallest set of reusable building blocks they’re named tertiary structural motifs, or TERMs, that would achieve this goal.Another hurdle in determining the set of universal TERMs that capture all structure in the PDB was the difficult task of sifting through 13 million candidate TERMs, and describing which residues and contacts in known protein structures they individually explained. “Our previously-developed, efficient structure search algorithm MASTER helped us resolve this – but the total amount of computational time involved was still quite large, so we had to make use of a computer cluster.” A computer cluster is a single logical unit comprising multiple networked-linked computers. Explore further Fig. 5. An EF-hand TERM. (A) The 31 nonredundant EF hand-containing instances of the TERM (gray) with adjacent structure (green). Calcium atoms from TERM instances are shown as yellow spheres. (B) TERM instances alone with calcium-contacting side chains shown with sticks. (C) Variability among TERM instances. Four instances are shown in gray: two EF-hand examples with varying loop geometries (surrounding structure in green) and two non–EF-hand instances (from PDB ID codes 3HNO and 1CB7, surrounding structure in cyan), including one with TERM segments belonging to different chains. (D) Sequence logo of nonredundant EF hand-containing matches of the TERM. Position 18 corresponds to the canonical EF hand loop position 1 (61). Mackenzie CO, Zhou J, Grigoryan G (2016} Tertiary alphabet for the observable protein structural universe. Proc Natl Acad Sci USA 113(47):E7438-E7447. Journal information: Proceedings of the National Academy of Scienceslast_img read more

Delhi govt to ban tobacco chewing from Monday

first_img“We have decided to come up with a notification to ban chewable tobacco in all forms from Monday in Delhi. Under this, no one will be allowed to sell, purchase or store chewable tobacco,” Delhi Health Minister Satyendra Jain told reporters on Friday.He said enforcement teams of Delhi Police as well as the health department have been asked to conduct surprise inspections across the city to ensure that the ban is implemented. “The teams have been told to be active on this,” Jain said. However, no such ban will be enforced on cigarettes. Health Department officials said there was a Delhi government notification in September 2012 which was in pursuance of a series of directions from the Supreme Court to ban gutkha in the city. Also Read – Need to understand why law graduate’s natural choice is not legal profession: CJIBut since the ban mentioned the term “gutkha”, the tobacco retailers started selling the components of gutkha (betel nut and raw tobacco) in separate pouches. So, the purpose of banning gutkha was not served. Therefore, the health department last year started with a new proposal to ban all raw chewable tobacco products in Delhi, a senior official said.According to officials, gutkha is also being supplied to retailers in Delhi from neighbouring states of Uttar Pradesh and Haryana. Stepping up its efforts towards tobacco control, the health department has also launched an innovative drive, creating a ‘Tobacco Aware Citizens’ Directory’ to spread an awareness about its harmful effects.Sources in the government said the ban on the sale, purchase and storage of chewable tobacco in all forms would be for the next one year and thereafter, the government will re-notify it. “Lieutenant-Governor Najeeb Jung has already given his nod and the government will issue the notification to ban chewable tobacco in all forms from Monday,” said a senior government official.last_img read more

S 24Pgs administration on war footing to ensure stellar turnout on May

first_imgKolkata: The South 24-Parganas district administration is leaving no stones unturned to ensure a good turnout in the last phase of the Lok Sabha polls scheduled on May 19.The district, with the four parliamentary constituencies of Diamond Harbour, Jadavpur, Mathurapur, Joynagar and almost half of South Kolkata, has the highest number of booths in the entire country at 8,550. The district is followed by Nagpur, North 24-Parganas and Thane in terms of total booth count, nationwide. Also Read – Rs 13,000 crore investment to provide 2 lakh jobs: Mamata”Apart from mobilising more than 6,000 vehicles including water transport and other arrangements for smooth ferrying of polling personnel, we have given utmost importance to risk aversion and disaster prevention. We are installing two temporary automatic weather stations at Gosaba and Patharpratima, for very specific and localised weather forecasts,” said South 24-Parganas DM Y Ratnakara Rao, who is also the District Election Officer (DEO). The district administration has taken lessons from cyclone Fani, for which it had elaborate arrangements for disaster management. “This district has perhaps the highest diversity in the country, with a blend of metropolitan, international maritime border sharing, as well as an archipelago of islands,” the DM added. Also Read – Lightning kills 8, injures 16 in stateThe entire Gosaba Assembly constituency under Joynagar PC which has 257 booths and nearly half of the Patharpratima Assembly constituency with 136 out of 293 booths, are located in remote riverine locations. “Arrangements are in place to make voting personnel reach these locations 48 hours in advance. The rule book says that voting personnel should reach their place of duty a day before polling,” a senior official in the district administration said. The official added that there will be speedboats at all important ghats, ‘Apatmitras’ who are specially trained in disaster management operation and other necessary standard operating procedure (SOP) in place. Sufficient number of CCTVs will also be installed at important locations. The Coast Guard, which has its base at Frasergunj, is sanitising the waterways on a regular basis as a part of preventive intervention. “We have made all DCRCs weather proof, taking lessons from the 2009 Lok Sabha elections when 200 EVMs were damaged due to inclement weather and machines were procured from Hyderabad on a war footing to address the crisis situation. With a large part of the district being located on the coastal belt, chances of natural calamity are always on the cards. So we need to be prepared fully in advance,” the official said.last_img read more

Its a crowded field but Canada Jetlines says it wants PVR CUN

first_img Travelweek Group Tags: Canada Jetlines, Jetlines VANCOUVER — Canada Jetlines says it intends to provide future service to several sun destinations in Mexico including Puerto Vallarta, Los Cabos and Cancun.The start-up ultra low-cost carrier, currently aiming for a summer 2019 launch, says it has reached agreements with Grupo Aeroportuario del Pacífico to provide future service to the Puerto Vallarta International Airport (PVR) and the Los Cabos International Airport (SJD), as well as Grupo Aeroportuario del Sureste (ASUR) to provide future service to the Cancun International Airport (CUN). “We are thrilled to announce future service to these airports,” says CEO Javier Suarez. “I have worked in this market extensively and have a deep understanding of how to operate successful routes in and out of Mexico. We look forward to providing Canadians with ultra-low fares for their vacation plans. With the money saved, Canadians will have the ability to spend more at their destinations; staying longer or in nicer resorts with their friends and family members. Our low fares will also encourage Mexicans to visit beautiful Canada.”Suarez joined Canada Jetlines in June 2018, first as Chief Commercial Officer and later as CEO, from Mexican low-cost carrier VivaAerobus where he was Vice President, Network Planning, Revenue Management, E-Commerce.Grupo Aeroportuario del Pacífico CEO Raul Revuelta says, “We at GAP are pleased to welcome Jetlines at our Puerto Vallarta and Los Cabos airports. During 2018, for the first time in history, we received a combined traffic of 10 million passengers at both airports; this due to the growing number of hotel rooms and the high quality of the touristic products offered at these amazing destinations. I am sure that our Canadian friends will have a wonderful time while visiting Puerto Vallarta and Los Cabos, and we at GAP will continue to work to provide them with the best airport experience.”And ASUR’s Customer and Route Development Director Alejandro Vales said, “ASUR is delighted to welcome Jetlines to our Cancun airport. A brand-new Canadian airline bridging new origins from Canada to our world-class destination will be a recipe for success indeed.”The long list of carriers flying Canadian vacationers to Mexico got even longer this month with low-cost carrier’s Swoop’s new service to Cancun, Mazatlzan and Puerto Vallarta.Suarez says Canada Jetlines’ ability to service these routes is subject to the completion of the airline licensing process and the receipt of applicable regulatory approvals. It’s a crowded field but Canada Jetlines says it wants PVR, CUN & SJD Thursday, January 17, 2019 center_img Share Posted by << Previous PostNext Post >>last_img read more

Love is love is love Labrador meets up with dolphin every day

first_imgLove is love is love: Labrador meets up with dolphin every day for a swim Share Travelweek Group Posted by DONEGAL, IRELAND — Would you swim across an ocean to be with your soulmate? One dog did, and he does it every single day in the name of love.Okay, maybe it’s not the length of an entire ocean, but to Ben, a lovable labrador in Donegal, Ireland, it may as well be because that’s how deep his love goes for his #1 pal and soulmate, Duggie.And if that weren’t enough to melt your heart, get this: Duggie is a dolphin.According to residents, Duggie has remained off the Donegal coast after her dolphin mate unexpectedly died. One day, she met Ben – who likes long walks on the beach – and the two hit it off.According to residents, Duggie has remained off the Donegal coast after her dolphin mate unexpectedly died. One day, she met Ben – who likes long walks on the beach – and the two hit it off. More news:  Save the dates! Goway’s Africa Roadshow is backSince then, the two mates meet up to swim every day, sometimes up to three hours at a time, said Ben’s human, Pat Doohan.“Occasionally a school of dolphins will go by and she will join them. When I see them I think she will forget the island and go back to her wild ways but she never does,” he says.So there you have it: love is love is love. Here’s hoping Ben and Duggie have a lifetime of happiness together!center_img << Previous PostNext Post >> Thursday, June 27, 2019 Tags: dog, dolphin, Lovelast_img read more

Good day And welcome to another week  We had som

first_imgGood day. And welcome to another week.  We had some great weekend weather which I took advantage of watching my son’s football game Saturday and daughter’s soccer and field hockey games yesterday.  None of the games resulted in wins, but I enjoyed myself in spite of the outcomes.  The labor data here in the US provided the equity markets with a pleasant outcome Friday as stocks ended the week on a positive note.  The dollar didn’t have such a good week, dropping just over one and one half percent vs. the major currencies.  This week will be dominated by the FOMC meeting here in the US and the German constitutional court ruling on the other side of the pond.But we will start with a recap of events on Friday.  The US labor department reported the biggest decline in factory jobs in two years, contributing to a disappointing increase in payrolls during August.  The US economy added just 96,000 jobs last month after a revised 141,000 increase in July.  The median estimate of economists surveyed by Bloomberg called for a gain of 130,000 jobs.  Factory payrolls declined by 15,000 workers last month and was the major contributor to the drop in jobs.  Details of the report showed the workweek shrank, and the number of industries hiring new workers plunged to the lowest level in almost three years.  Definitely not a good sign for the prospects of the unemployed factory workers, and exactly what the current administration didn’t want to see.  A lot was made of the rebound in the auto industry, but the data showing manufacturing jobs have decreased throws cold water on that line of thought.But the President and his supporters can still point to the unemployment rate which dropped to 8.1%.  Yes, the number of people working dropped, at the same time the unemployment rate also dropped.  Much like last month, the unemployment rate and monthly jobs data seemed to be in conflict.  But unlike last month when the difference was blamed on inconsistencies in the generation of the reports, this month’s conflict could be more easily explained.  Americans are leaving the workforce at a faster pace than they are entering it.   368,000 Americans left the labor force last month, most of them giving up looking for new work.  The participation rate, which shows the share of working-age people in the labor force, fell to 63.5% from 63.7%.  There are currently fewer working-age people in the labor force than at any time since September 1981.  That one piece of data is a great indicator of just how bad things are here in the US.The labor data have increased the odds of action by Bernanke this week.  The Federal Open Markets Committee will be meeting on Wednesday and Thursday, and the Chairman is expected to announce another round of stimulus for the markets during his press conference Thursday morning.  During my presentations out in San Francisco, I shared my thoughts that there was just slightly higher than a 50% chance of another stimulus announcement this month.  I felt it was just too close to the Presidential election for the Fed to act; as they try to avoid the appearance of being too political.  But Chairman Bernanke has pointed toward the stagnant labor market as the key to further stimulus, and Friday’s report should provide him plenty of cover to avoid looking too political.  The markets are certainly expecting Bernanke to announce another round of stimulus; I saw a survey this morning which put the odds of another stimulus announcement this week at 99%!!The question now is exactly what will Bernanke announce.  Some now believe he will model his new program off of the ECB’s, announcing unlimited additional bond buying.  This would allow the Fed to continue purchasing bonds until they feel the economy shows more definite signs of recovery.  The advantage of this program, as shown by the reaction to the ECB’s announcement last week, is that the markets can’t question the ability of the central bank to take action.  But unlike the ECB program which is solely aimed at sovereign debt within 3 years, the Feds new program will likely be aimed at mortgage debt with longer maturities.  Another difference is that the ECB won’t buy bonds unless a country asks for a rescue, and then the bond purchases will come with austerity commitments by the country seeking help.  The Fed’s quantitative easing program won’t have any austerity measure tied to it, in fact it is more of an ‘anti austerity’ program adding to our deficits and debt in the interest of stimulating growth.Friday’s labor report and the resulting increase in expectations for another round of stimulus led to a rally in gold and treasuries and a continued fall in the value of the US$. Investors, worried about the inflationary impact of additional stimulus measures, took gold to the lofty levels it was trading at back in March.  While prices moved down a bit going into the weekend, gold is still firmly entrenched in an upward trend and certainly looks like it will challenge it’s former highs.The dollar lost ground vs. most of the major currencies on Friday, ending a week in which the dollar index fell over 1.5%.  I guess the ‘Chuck is off the desk rally’ held true again.  In years past, whenever Chuck is off the desk for an extended period, we always seem to have a currency rally, and last week’s dollar action was a confirmation of this pattern.  As I explained last week, the reason for the fall in the US$ is a fairly simple case of supply and demand.  The Fed will be creating a whole lot of dollars which it will be using for the bond purchases, and this increase in supply will eventually lead to inflation.  It may not be reflected immediately in the price of goods and services, as international investors still seem to have an appetite for the freshly minted currency.  But eventually the demand will slacken, and at that point we could see a spike in inflation.  Bernanke has told us he is aware of this risk, but he is convinced the Fed can pull the newly created dollars back out of the markets as fast as he is adding them.  I guess we will just have to wait and see if he is correct, but the markets are starting to hedge their bets.The ECB action last week helped the euro push above the $1.28 handle, but it gave it back and is hovering just below it this morning.  Concerns over the German Constitutional ruling due out this week, combined with renewed concerns in Greece put a lid on the appreciation of the single currency.   The German court is expected to give its ruling on Germany’s participation in the European Stability Mechanism on Wednesday.  The court is expected to allow for Germany’s participation, but currency traders are worried they may put stipulations on any future participation of Germany in European bailouts.  Both German Chancellor Angel Merkel and Finance Minister Wolfgang Schaeuble are confident the German court will allow the establishment of the ESM, allowing the bailouts to continue.Greek Prime Minister Antonis Samaras is due to meet officials from the ECB, IMF, and EU today.  Samaras failed to secure an agreement to the 11.5 billion spending cuts required for the release of the next round of rescue funding.  After this year’s two elections, Samaras is operating with a minority government and must get his two coalition partners to agree to the austerity measures.  At least one of the two is demanding the cuts be combined with growth measures. “The recession is deep and if these measures aren’t accompanied by growth measures, they will be ineffective,” according to Greece’s Democratic Left leader Fotis Kouvelis.  “Our European partners need to know that Greeks can’t take anymore.  Nothing can be taken for granted.”  Sounds like we could be in for some more volatility in Greece.  We warned you that the rollercoaster ride of the euro isn’t over yet, so just make sure you are strapped in!The Canadian dollar rallied to a yearly high this morning after a report showed employment in our northern neighbor rose faster than forecast.  Canadian employment rose by 34,300 jobs in August, offsetting a decrease of 30,400 the month before.  The unemployment rate remained at 7.3%, right on target with median forecasts.  While the number was definitely a positive sign, the Canadian economy is expected to remain in a slow growth mode.  Last week the Bank of Canada left the key interest rate unchanged at 1% in an effort to encourage investment and consumption to drive growth.Carney has reflected a hawkish tone, as increases in the prices of commodities which make up the majority of Canada’s exports threaten to push up Canadian inflation rates.  The increase in commodity prices caused the BOC to reiterate that interest rates may have to be raised in order to prevent inflation from accelerating.  Following last week’s BOC meeting, Carney said “some modest withdrawal of the present considerable monetary policy stimulus may become appropriate.”  Higher interest rates would give even more support to the Canadian dollar, sending it to new yearly highs.The Australian dollar moved lower in early European trading after a report showed China’s imports slowed.  Both Canada and Australia have commodity driven economies, and the commodity markets are dependent on strong demand  from China.  A report released earlier today showed China’s imports slid 2.6% in August from a year earlier, the first decline since January.  The same report showed Chinese exports rose 2.7% and a different report showed production increased 8.9%.  The Chinese President sounded a warning, saying China’s economic expansion faces ‘notable downward pressure’.The pace of the global economic recovery is going to be dependent on Asia, as both the US and Europe’s economies continue to struggle.  So the news that Chinese imports slowed are worrying.  China has been slowly changing from an export driven economy into one driven more by internal consumption, so the slowdown in imports is concerning.  And concerns regarding the Asian growth prospects were heightened further with the release of Japanese GDP measures which showed the economy grew at just .7% during the 2nd quarter, less than the preliminary reports which predicted a 1.4% increase.  The median forecast of economists was right in the middle of the two figures at 1%.  The spending which was necessitated by last year’s earthquake and tsunami helped push GDP up slightly, but that spending is now over and gridlock in the Japanese parliament is preventing any additional stimulus.  There is a good chance the Japanese economy could slip back into contraction in the 3rd quarter.  I continue to warn against investments in the Japanese yen, and actually look at it as one of the currencies which could fall the most as investors start to move back into higher yielding currencies.To recap. Friday’s monthly jobs reports showed a US economy which is still struggling to recover, and put the possibility of a stimulus announcement by the Fed at almost 100%.  The future of the ESM (and therefore the euro) rests in the hands of a German Constitutional court which is expected to rule later this week.  But the court is widely expected to rule in the euro’s favor, and the single currency continued to rally.  The possibility of another round of stimulus had gold rallying along with the commodity currencies.  The loonie hit a yearly high but the Australian dollar moved lower after a Chinese report showed imports decreasing.  Japan’s GDP came in at ½ of what was originally predicted, and further stimulus isn’t in the cards for the Japanese yen.Currencies today 9/10/12. American Style: A$ $1.0353, kiwi .8106, C$ $1.0239, euro 1.2781, sterling 1.6009, Swiss $1.0562. European Style: rand 8.1789, krone 5.7822, SEK 6.6390, forint 223.04, zloty 3.2178, koruna 19.177, RUB 31.7243, yen 78.28, sing 1.2365, HKD 7.7559, INR 55.3875, China 6.3377, pesos 12.9622, BRL 2.029, Dollar Index 80.336, Oil $96.46, 10-year 1.67%, Silver $33.6925, Gold $1,734.57, and Platinum $1,596.75That’s it for today.  Tough loss for both our football teams this weekend.  Mizzou looked good for the first three quarters in their opening SEC game vs. Georgia, but just couldn’t hang with the dawgs at the end of the game.  And the St. Louis Rams dropped their season opener during the final 10 seconds of the game played up in Detroit.  My son’s high school team got routed on Saturday morning after their game Friday night was delayed because of a storm which rolled through during the first half.  Not a good football weekend, but I enjoyed it still as the weather was absolutely fantastic Saturday and Sunday.  The trading floor has a new look this morning as workers installed several new desks over the weekend to keep up with our growth.  Things are a bit cozier now and I’m sure the noise volume will increase as we put butts in all the new seats; but that is what I like about being out on the floor, all the noise and activity are what makes it a trading floor.  Gone on a bit long this morning, so I will just thank all of you readers for sharing your morning with me.  Hopefully this will be a Marvelous Monday and a great start to your week!Chris Gaffney, CFA SVP & Director of Sales T. 314-951-1619 EverBank World Markets 8300 Eager Road, Ste. 700, St. Louis, MO. 63144 EverBank.comlast_img read more

A 38yearold man from Texas is dead after a singl

first_imgA 38-year-old man from Texas is dead after a single-vehicle crash Friday afternoon.Sergio Herrera died at the scene when the vehicle he was driving left the road and struck several trees.Alabama State Troopers said it happened at 4:50 p.m. on Interstate 59, near the 54 mile-marker about 14 miles north of Eutaw.The crash is still under investigation.last_img

The presence of Juul ecigarettes in high schools

first_imgThe presence of Juul e-cigarettes in high schools across the country is increasing — and so is Juul Labs’ lobbying presence in the nation’s capital.The company, which bills its product as “a satisfying alternative to cigarettes,” spent $750,000 on lobbying during the last three months of 2018, according to lobbying disclosure forms filed with Congress on Tuesday. According to the filing, Juul advocated on the issue “regulation of e-cigarettes and vaping products designed to improve the lives of adult smokers.” This most recent filing was also the first quarter when Juul indicated it lobbied to support legislation that would stop businesses from selling tobacco products to people younger than 21.The company started its D.C. lobbying operations during the second quarter of 2018, though it only spent $210,000 then. It has increased its spending in the two quarters since.”We have grown our D.C. team to engage with lawmakers, regulators, public health officials and advocates to drive awareness of our mission to improve the lives of the world’s one billion smokers and to combat underage use so we keep JUUL out of the hands of young people,” Juul spokeswoman Victoria Davis said in an email to NPR. “As we said, the numbers tell us underage use of e-cigarette products is a problem that requires immediate action.”The Food and Drug Administration cracked down on stores selling e-cigarettes to minors in September of last year, declaring use of the products had reached “epidemic” levels among America’s youth. The Center for Disease Control says 1 in 5 high school students used e-cigarettes in 2018.In addition to regulatory issues, Juul also indicated it lobbied on tariffs of products manufactured in China. Because of filing procedures, it is unclear how much of its lobbying spending went toward this issue versus e-cigarette policy.The company’s lobbying roster includes Jim Esquea, who was assistant secretary for legislation in the Department of Health and Human Services during the Obama administration. (The FDA is part of HHS.)Juul also used outside firms to influence legislation, as companies commonly do. These included S-3, Empire Consulting and Sims Strategies.After Juul’s lobbying boost in the most recent quarter, Juul came in as the fourth-highest spending cigarette manufacturer. Other top companies included Altria Group ($3.2 million spent on lobbying), Philip Morris International ($1.2 million) and Reynolds America ($790,000). Copyright 2019 NPR. To see more, visit https://www.npr.org.last_img read more

The Impossible Burger Is Coming to Burger King

first_img White Castle was just the start: Impossible Foods is now partnering with Burger King, launching the Impossible Whopper for a test starting today at 59 Burger King outlets in St. Louis, Missouri. It’s an entirely different burger to the sliders served at White Castle, and that means there’s more Impossible Burger non-meat involved.It’s equal parts silly April Fools’ teaser and actual product launch at the U.S.’s second-largest burger chain. For now, the company is staying quiet on whether there’ll be a nationwide roll-out. The Whopper launch comes after another regional debut: a Philly Cheesesteak that’s currently exclusive to, well, Philadelphia of course.If it’s been a while since you’ve had a Whopper, or you’ve been vegetarian for a while, the Impossible Whopper includes a flame-grilled, (improved) plant-based burger patty, with lettuce, tomato, pickle and onion toppings. Oh, and don’t forget the mayo and ketchup. This story originally appeared on Engadget Add to Queue For now, the company is staying quiet on whether there’ll be a nationwide roll-out. Free Webinar | July 31: Secrets to Running a Successful Family Business Image credit: Impossible Foods via engadget Fast Food Mat Smith 1 min read –shares The Impossible Burger Is Coming to Burger King April 1, 2019 Learn how to successfully navigate family business dynamics and build businesses that excel. Next Article Register Now »last_img read more

Podcast Cannabis Investing Tips for NonMillionaires

first_imgPodcast Get 1 Year of Green Entrepreneur for $19.99 Image credit: Codie Sanchez Podcast: Cannabis Investing Tips for Non-Millionaires 15+ min read Jonathan Small Next Article Add to Queue May 23, 2019center_img Cannabis stocks are all the rage. IPOs valued at billions of dollars are popping up on Wall Street and the Canadian Stock Exchange, and private equity funds are investing multiple millions in cannabis companies.If you’re watching all this from the sidelines, wondering if you’re missing out on a golden opportunity but not sure what to do about it, you’re not alone. Many potential investors believe they don’t have the cash to get in the game, and in some instances they’re correct. Due to regulations, many funds are not even permitted to accept investments for less than $200,000.On this week’s Green Entrepreneur podcast, we talk to Codie Sanchez, a partner at Cresco Capital Partners, about how to invest in cannabis companies even if you don’t have a lot of cash. This is a full transcript of our interview. Related: Why Former NBA Star Al Harrington is Betting On CannabisYou started your career with lots of spreadsheets and more traditional investing, and have now transitioned to the cannabis industry and business. I’m curious to know why you made that change.I think there might be some parallels to a lot of people’s story in this space in that once you figure out investing, and particularly if you’re trained to do it, once you figure out how to find dislocations in markets – something where everything just doesn’t fit together perfectly so that people smarter than you and who have more money than you do can take advantage of it – when you see those dislocations, you learn to jump on them quickly. In investing we call this arbitrage. That’s when something typically costs less than it should or costs more, and you can take advantage of those things happening.So I saw that happening in this space. I’m certainly no genius or clairvoyant in it; it really just came down to the math and looking at math in this space as an investor and saying there’s a real, tangible generation of wealth creation event happening here.But I have to say that probably math would not have been enough if I was going to call my mom and tell her I was going to go into the cannabis game. [laughs] It was a little bit deeper than that.I started off my career, even before I was traditionally investing at firms like Goldman or State Street or Vanguard or doing some of the venture stuff, I was actually an investigative journalist. I don’t know if we talked about this before, but I worked at the U.S.-Mexico border. We were writing stories about human trafficking and drug smuggling.Wow, that’s intense. What part of the border?The part that you would probably know is right across the border is a place called Juárez, [across] from El Paso, Texas.Yes, it’s notorious.Exactly. They call it Ciudad de la Muerte, the city of death. It’s a pretty tough place to be young and female. Thy have hundreds and hundreds a year of murdered women there for some reason.But what that taught me, besides to be relatively jaded, is that as an investigative journalist you really don’t take anything at face value. You have to question everything, find the root of why things happened, and then dig deeper. You really can’t let stigma get in the way, or people’s assumptions; otherwise you’ll never write a good story.This tendency taught me to do this deep diving, and that’s when I got to the math, and also a little bit of the heartstrings. I think anybody in this space has a story – and I know you’ve shared some of yours too – about the impact that it’s had. I dug into that a little bit in particular with veterans, which we can talk about later. We fund an initiative called Texans for Veterans, which is trying to give veterans in Texas access to research and medicinal marijuana.How many times in your lifetime do you get a chance to be a part of a generational wealth creation event where there’s massive dislocation so little guys can play too, because the big guys aren’t all allowed to with their legal background, and then in tandem you get to make a huge impact – I think in multiple areas, but certainly with mental health and veterans, which I’m very aligned with since my partner is one.Your partner is a veteran?Yeah. My significant other. He’s active duty military right now, in the Navy.Has cannabis made an impact in his life?No, they’re very, very highly regulated. He does some particular things for the military in which that’s not allowed. Actually, for the military overall, if you use cannabis, you can lose your VA benefits, be fired. There are huge repercussions. But what he and I both have done is be a part of this nonprofit that essentially is trying to push for access for veterans.He’s the first one to say, “Gosh, if I could use it, I absolutely would,” for the chronic inflammation that you get from being deployed so many times, and certainly from – everybody comes back with some type of hyperawareness and certainly that stress that comes from being in a warzone.And you’ve seen firsthand that cannabis has helped veterans with those symptoms you’re talking about?Oh, absolutely. There’s one gentleman whose name is Keith who’s a bronze medal winner. He served in three different branches of the military, lifelong veteran. He was actually here in D.C. when the Pentagon was hit and was one of the first responders because he was a trained nurse. He’ll very publicly say – so I can say his name – that without cannabis, he doesn’t know if he’d still be around because of the opioid cocktails that they were giving him. He just wasn’t reacting well to them. He had a lot of anger and anger issues.Now with cannabis, he has a lovely family and wife and a cute dog. I think, while that is not quantifiable because there’s not enough research on it, there is certainly a lot of qualitative human interaction that you can see that it makes a differenceI know there’s no such thing as easy money, but I think people who are not necessarily directly involved in the industry, whether they’re touching the plant or not touching the plant, might have some interest in investing, at least, in the industry. That is what you do. Your clients are generally big spenders, right? To get into your fund – tell me a little bit about the fund that you work with.It’s called Cresco Capital Partners, and it’s a private equity or growth equity fund in the cannabis space. What’s interesting is due to the regulations around a lot of how these funds are structured, they actually mandate that you have higher minimums, typically because you’re only allowed so many investors in the fund and they have to be accredited. So even if I wanted to allow everybody in at $5 or $10, it’s very hard to do that at this stage.Now, that changes, and as you get more funding you can create a more complex fund business. But at this stage, this is our second fund, which is $55 million. The first one was around $25 million. We have co-investments, so we’re probably right around somewhere like $100 million in assets. The minimum is $200k, so that does make it difficult for everybody who wants to invest. It’s still one of the lowest in the space. I’ve tried to keep it lower. It’s an administrative nightmare to do so.Image credit: Codie SanchezBut I think the whole point of this industry is democratizing access, right? I think that’s what we’re going to talk about today – how to do that, whether it’s investing with somebody like us, or ramping up to invest with somebody like us, or doing it on your own. We can talk about all of the above and how I started investing in cannabis.Let’s talk first of all a little bit about what you do with the money that people invest with you. Who has Cresco invested in and some of the companies that are under your purview?This is where I get excited. There’s nothing more fun than giving the lifeblood, which is capital, to really incredible organizations. In this industry in particular, it all moves so fast, you get to see what that money does that you give these companies quickly and all the people you’re able to serve one way or the other.We’ve invested in a lot of interesting companies. We’ve had about seven exits thus far, which means companies that have been sold or gone public or done some sort of merger. We invested in some names probably people know, like Acreage, one of the biggest companies out there, who’s had a little bit of news.They recently merged or were acquired by Canopy Growth.Yeah, for a tiny amount, $3.5 billion. We’ll see. It’s the right to buy them, so it’s pending that legalization happens – but you covered that well.Then we invested in GTI, which other people probably know. We invest in a company called Ebbu that was bought by Canopy Growth for just shy of $500 million. We invested in another company called Form Factory, which was also sold. That one’s interesting. It’s kind of a co-packing business and a branding company. And then we have lots of up-and-coming companies in the portfolio, like Prohibited, which is a big media company. You guys have done stuff with them. I think that company is fascinating because they’re doing brands too and leveraging this medium platform to maybe figure out who will be the future brands of cannabis. And then we invest in another company called Sublime. Great product.I love their music.Oh, the music? [laughs] Well, these guys are not of the ’90s. They were probably born around that time period. But they do these little things called Dosies, which are micro-dose, almost. They look like Tic-Tacs. They’re manufactured by the same manufacturer of Tic-Tac to do the candy coating that they do. So they taste like orange Tic-Tacs, and they’re great for sleep. My grandmother has a problem with her hip and she can’t sleep, so she uses Dosies now. I got turned onto it. One of my partners, who’s another woman and a mom, said after you have kids you really never sleep again, and these helped her. So I thought it might work for my grandma, too.You oversee a $100 million dollar fund. I’m sure you get pitches all day long. What are some of the main things that you look for in a company? I’ll tell you one thing, my inbox never gets to zero, that’s for sure. We’ve screened over 1,800 companies and hundreds a year, and what we look for is twofold. One, we’re not seed stage, meaning we don’t invest on the early side of the business like a tech company might when there is no revenue yet or no product. We invest in the growth equity space. Typically we’re looking at companies that are already generating anywhere from $1-$20 million in revenue. We need them to be revving a lot in order for us to invest.We definitely are interested in companies that first and foremost – which I think any good investor will tell you –you’re really betting on the team. The idea is important, but as any entrepreneur knows, there are going to be pivots, there’s going to be heartbreak, there’s going to be backstabbing. It’s like Lifetime TV if you want to go run a company. You have to pick people that are resilient to do it. So we do a ton of time on due diligence on the teams. I was just talking to a big MSO today, actually, and one of the sales points for them –That’s a multi-state operator, for those taking notes at home. Good one. The thing that sold me was they are a multi-state operator and their COO is one of the smartest operators I’ve ever seen. That’s always a good trick if you’re looking to invest: figure out, can they actually operate? Because cannabis is not a simplistic business. It’s highly complex. You want to make sure you have somebody that can handle it. Let’s get to the million dollar question, which is: I don’t have a million dollars, but I want to be a player in this business, or at least I want to invest in this business. Where do I start? What do I do? If I know that a lot of the really successful funds such as yours have a pretty high bar of entry, unless I have $200,000 – which I don’t. I think the goal here is to do just that, to get your seat at the deal-making table and to get you deals and access into the space that really outstrips your network. The secret is, I really believe wealth is made on the private side. If you look at anybody who has accumulated wealth – not just rich, but real wealth – it’s because they’ve done investing either on real estate or in their own company on the private side. That’s just the “why” of this even mattering.Explain that a little bit to me. On the private side, meaning they’re not public companies that they invest in? It’s very hard to make generational wealth or real wealth by investing in public stock markets. You can see that very quickly. Say you put all the faces from the Forbes 100 list, billionaires out there, on one page. What you would notice if you went through all their bios is not a single one of them made their money from smartly investing in public stocks.The brilliant Warren Buffett, Carl Icahn, they only move when they have three things. The first one is an unfair advantage. For instance, Carl is an activist  . He can go bother the founders of the company until they make changes to the actual company and make him money. So you need an unfair advantage in some way.Your unfair advantage, Jon, might be that you have really incredible deal flow because all these entrepreneurs want to pitch you all the time. So you might be able to see trends and know people and be a connector because of all this deal flow that you see.So one is your unfair advantage. That’s what you need. The second thing that you need is intimate knowledge. Not insider knowledge. You can’t have anything illegal. But you need intimate knowledge of the industry, the company, whatever you’re investing in. You really can’t get that with public stocks because otherwise it would be insider information. So intimate knowledge meaning you have some access to their financials, or just that you know an industry intimately?I believe access to their financials or access to the actual founders or access to their actual distributors. Something beyond what the news and Jim Cramer could scream at you on CNBC. So you need that.Then the third thing that you need is the ability to affect the outcome. That’s how we invest on the private side because by giving them capital, we can talk to them about how they’re going to exit, who’s going to buy them, if we could help them structure the exit on the backend, all of that.Those three things are really key to massively investing. But we’re talking at a super high level. We’re not all going to have that on Day 1, but you should always have that in the back of your mind. It’s why I’m really worried about anybody who’s a price speculator.What does that mean?Price speculator basically means – everybody knows about the cryptocurrency crisis. The housing crisis really was no different, and there was also the internet bubble, and then if we go way back there was tulip mania, which was where people were paying hundreds of dollars for a tulip bulb. Nuts.It’s all the same thing, though. It’s all called price speculation, which basically means people invest in something just because they think the next guy is going to buy at a higher price and they’ll be able to sell after he gets in. But they don’t believe that there’s real value in what they’re investing in. They’re price speculating that the price is going to go up no matter what.We’ve got to be careful about that. There’s a little bit of that in cannabis, so on the public side I’m really cautious about investing. We talk about price a lot. Warren Buffett talks about that too.It seems really out of whack right now on the public side, the valuations of the companies. Yeah, I think so. I think you’re nailing it. I don’t have a crystal ball. If I did, we’d be on my yacht while we’re recording this podcast. But what I think is important to think about on the public side, or any time valuations or the price of stocks is concerned, is it might be really exciting the numbers that they’re at, and they might do all the things they need to do in order to grow into that price, but I’m always looking at the downside.Does it make sense for the top 10 cannabis stocks to be worth 4x more than the top 10 biotech, tobacco, pharma, or healthcare stocks, from a price-to-sales perspective (which just means the price that they’re worth versus how much they actually sell)? I would say I don’t know. It’s a growth industry; it could be, but probably not. The key to investing there is always buy low, sell high, and train your brain on that, to focus on price first before excitement.You gave us the three attributes or the three keys to think about and ways to position yourself. You had also mentioned you need to make relationships, you need to network outside of your network. How do you recommend doing that?Codie: I think there are a couple different ways. One, if you want to invest, in my opinion, or if you want to do anything – say you want to play baseball. The first thing that you should probably go do is watch a baseball game. Then you should probably go try to play a baseball game amongst you and your friends. Then you should probably try to figure out who are the reporters that cover baseball. Then you should probably try to go to three or four conferences of people who are talking about baseball or selling baseball gear or something related to baseball.It’s not dissimilar to investing. You go where the game is played. In cannabis, in my opinion, that would be places like ArcView, which is kind of like AngelList, if you know what that is. AngelList is where you can go and invest in lots of different startups, but at very low dollar amounts. ArcView is similar but for cannabis, and they also have conferences. So I think you go to a couple ArcView conferences, you join that.They should be, in my opinion, getting smart. They’ve got to listen to all the podcasts on Green Entrepreneur, and then go over to CannaInsider podcast, and then go and look at some of the investor intelligence reports like Cohen. Don’t spend a lifetime; do this in a weekend. You can binge-listen to a couple podcasts, binge-read all the investor intelligence on MJBiz or Green Entrepreneur or Cohen.Then you start reaching out. Then you try to go to an ArcView event. Schedule one. Then you email all the speakers at the ArcView event. Give yourself a timeline. You have 30 days to get smart on it.What’s crazy is, after you do those three things – listen to a ton of podcasts, read as much as you can about the industry, and then get hooked up to an industry group and go to one of their conferences – you are smarter than 90% of the population on cannabis.What’s the conversation you have with these people that you connect with through ArcView or these different platforms that you have recommended? Is that the moment when you present yourself, about who you are and what you have to offer?I think you have to first have a belief that I’ve found to be true across every industry I’ve been in, which is that if you go where the game is played because you want to be in the game somehow, you will have opportunities presented to you that you never otherwise would.That’s my promise to you. If you do these three things and you go to where the game is played with a curious and open mind and dig in, you’re going to have stuff come up that you didn’t exactly realize how the opportunity was presented to you, and you wouldn’t have picked it exactly this way, but it’s even better than you thought.If you have that belief, then when you go, I think there are two things that are super important. One is curiosity. We’re all egoists, right? I like to have my ego stroked. I’m sure you do [laughs] Never. But the truth is, if somebody comes up to me and says, “Codie, I’ve been reading your stuff, listening to your podcast here, I saw you speak here, and I’m really curious as to what you meant here” or “I’m really curious, what do you think about this?” or “how would you enter this space?” or “why did you do this particular move?” – those small, tailored questions to somebody’s ego, showing that you’re truly curious, not faking it – that goes really far. If you do that to five or ten people, the likelihood is you have two to three to four who want to engage with you. So that’s where I’d start. Curiosity.But then I think the second thing you’ve got to do if you actually want to get in – I just interviewed an analyst today, actually, for our firm. The way he came to me was similar to this. Reached out, said he had listened to a few things. But he did something different that I loved, which was “I’ve been doing research and analysis on the space. I’m in grad school right now and did some models on vertically integrated companies” — which are companies like Acreage, let’s say.So he said, “I did some research on these guys. Would that be useful to you?” I was like, “Huh, that’s interesting. Yeah, sure, I’ll take a look.” I looked at it. The models were actually really good, so I followed up with him. Right now I’m looking at the lab testing space, for example. Every time somebody wants to sell you cannabis, they’ve got to go make sure that they take it to a third-party lab to see if it has any sort of pesticides in it or if it actually is THC at the level that they say it is. I’m interested in that space. So I said, “Why don’t you try to apply your thought process to this lab space?” He did it, did a great job, and I’ll probably offer him a job.So that second key is not what they can do for you, but what you can do for them. If you provide value to people who are in positions of power, that is so rare – so rare – that they are going to want you in their circle.Right. There’s an example of somebody who might not have had $200,000 to invest in the fund, but had an expertise that you appreciated and needed.Absolutely. And if you’re an employee in a fund, you get an allowance where you can invest much less, so you don’t have to put in $200k if you actually work at one of these funds. Even if you’re in admin.What are some common mistakes that you see people making?First is be careful with public stocks. If you’re going to do it, be fine losing the money and be prepared for a lot of volatility. I say that because there are also some great public stocks, so I’m not saying you shouldn’t do it; just be cautious.The second thing I see people do that makes me nervous is they just go and invest in one company right off the bat. Everybody’s raising for cannabis something or other these days. Even if it’s just the $1,000 that you have to invest, it’s really risky to throw that out there. It’s called angel investing, but it’s risky to do that with the first couple companies you’ve seen especially.So I think the biggest thing you’ve got to get used to if you want to be an investor is saying “no” upfront. You’re like the hot girl at the bar. “No, no, no, no.” You want to go on a lot of first dates, but you don’t want to get married to somebody – you don’t want to give them your money – until you’ve gotten a feel for this weird industry and how to do some investments. Don’t make your first investment when it’s been given to you.And Lord, I made some bad investments when I first started, so don’t feel bad if you did. But I think they say that the best way to make a million dollars in angel investing is to start with three, which is the same for vineyards too.So diversify. Do a fund.Yeah, do a fund. ArcView is the only one that I know of in the cannabis space. I don’t want it to feel like I’m doing a commercial for them. But you can go to these angel investing groups. The goal that I had when I first started investing was to invest alongside somebody that’s smarter than I amHow do you do that? Well, you can go to something like ArcView and listen to all of the companies pitch. It’s like YCombinator, which is famous in tech circles as being an incubator. Go to ArcView, listen to everybody pitch, and then see and ask them what other investors are investing in their company besides you. Then you very easily reach out to those people and say, “Hey, I’m Codie and I’m looking to invest in XYZ Cannabis Company too. Do you have a minute to talk so I can understand why you’re investing?”Once you are in the investing circle, it’s much easier to get doors open for you. So invest alongside people that are smarter than you. You can do that by starting at something like ArcView, or I think you can do that in a fund structure.Or you can do that by following some of the big names in this space, like what is Steve DeAngelo investing in? He probably has interesting insight, being in this industry for a long time. What is Jonathan investing in? He’s seen a lot of different cannabis companies. So look for those influencers and then see if you can get a little piece of the pie and put in a small amount of what you can.Should we apply the same sort of criteria that you apply when you’re looking at companies? You said that you say “no” a lot. What are some red flags that you would say “no” to? What would you see in a company that you would be like, “no”? Or what should I see in a company where I might have second thoughts? I think when you’re an early angel investor, you should never invest in a company that doesn’t have revenue. There’s too much deal flow, especially in cannabis, there’s too many companies to invest in somebody that has never made a dollar. So I would not do that. Look for companies that at least have a couple hundred thousand dollars to a million plus in revenue.What you’ll be amazed by is they’ll take your money – you might not have much, let’s say, but if you can provide some other type of value, some sweat equity – these startups are usually strapped for cash and for help. So you can probably even leverage your sweat equity a little bit there. But I would start with don’t invest if they’re pre-revenue. I think that’s way too much risk upfront.Then I would say also, be really careful about investing in friends who are not absolute rock stars who have already done this before. Maybe they had already run an alcohol distribution company, so now they’re going to go into cannabis distribution. That makes a lot of sense. But otherwise, be careful about funding friends early on, before you really know how to analyze if they’re capable or not. That’s where a lot of people lose money.You said that you want to make sure that you like the team and are impressed by the team that is running a company. Will you have that kind of access as somebody who’s new to the game? It’s not like you can call up every CEO. You’ll have access because of who you are and your status in the industry, but how does one – should you just do your own research online? How do you find out more about who these people are?One way you can get access is through special purpose vehicles. What a lot of people do when they don’t want to invest or don’t have a ton to invest is they might pool their assets. It’s pretty inexpensive. You create an LLC, which basically costs nothing online these days, and that LLC allows you – say you have $10,000 that you could invest, and a couple other people have $10,000 that they could invest, and you pool it together and now you have $100,000.You can make yourself sound very fancy. “I am in charge of Cannabis, Inc., which is an LLC of investors in the cannabis space. We’re analyzing companies.” So with very little work and with very little money, you can actually get a seat at the table and say “We have $100,000. We’re looking to deploy it, and maybe it’s with your company.” Then you can get better access, certainly.Or you can join into somebody else’s syndicate or join angels groups. There’s CannaAngels – almost every city has a cannabis angel network, and if you join one of them and you pool all your resources together – but you don’t have to do the actual work – then you can get real access.How quickly will you see an ROI?Well, in cannabis it’s been faster than it typically is. Most venture capital or private equity funds are 5-year funds, so your money’s locked up for 5 years with a 2-year extension, meaning they can extend that 5 years by 2 years if they want to. That’s typically because it takes that long for a company to have a liquidity event, which means when they sell or you get your money back in some way.So the typical thought is 5 to 7 years, which I know to all of us who use Uber Eats and expect our food to get delivered in 7 minutes, seems like an eternity. [laughs] But that’s standard. If you’re going to do this, it has to be long money, and in my opinion, you have to want to learn and make money.Our first fund, we returned the capital in 3 years because cannabis is moving so fast. But that is what draws people to public stocks, I think, a lot. It’s short-term, there’s an ability to make money, and it’s a lot more rewarding to that endorphin-heavy brain of ours that wants immediate feedback loops. If you’re seeing it too quickly, there might be something going on here that’s not right?In my opinion, yeah. I don’t like price speculation, which I think is entirely what crypto is about. I think blockchain is different, but yeah. You always worry if you’re at an airport somewhere and the shoeshine guy is giving you stock tips about cannabis companies or about cryptocurrency companies.The stock market is really there to help investors beat inflation over the long term. You earn your 10% per year, which helps you beat inflation, and compounding investing over time leads to you making enough money to retire, theoretically. So I’m always nervous if the stock market is looked at as an immediate cash cow. That’s probably not sustainable.As far as the type of cannabis companies to invest in. Tell me the top 3 that you should be looking at and top 3 that maybe you should pass on?I got offered a really interesting deal in Colombia, actually, by descendants of Pablo Escobar to grow cannabis in Colombia [laughs] I passed on that one. But in all seriousness, cultivation is something that I worry about as the price of flower or the actual cannabis smokeable plant goes down. That’s just natural. It is a plant and it is agriculture, so that’s going to happen as the markets get more efficient. So I’m not running to give money to people who are purely doing grows. I would stay away from that. I don’t think I’m the only one doing that.I would stay away from brands that are not amazingly executed and with the ability, proven and actual, to scale. There’s a lot of little micro-brands around, and I think many of those will die a death of a thousand papercuts with California regulations and others. So be careful about that space.I also think I would be careful about any sort of tech that mimics something that’s done by a company outside of the cannabis space. People say to me, “I’m going to be the oracle of cannabis,” and my response is, “Oracle will be the oracle of cannabis.”I wouldn’t do that because eventually this game will change and those companies – perhaps they get bought, and there are some instances where that could be the case. But I’m hesitant of that space. So those would be the three I would stay away from.And the three that seem to have a lot of opportunity?Up until now — and I think it’s still the case — multi-state operators have done incredibly well. They’re out there doing a land grab, trying to grab as many different dispensaries and the grows associated with the licenses in each state for them.So these are cannabis brands that operate in many different states because they have, like you said, dispensaries and grows in a bunch of different states? Exactly. It’s not dissimilar to a company that distributes, like Whole Foods for instance, across multiple state lines and grows all their own produce and has a ton of white label brands and everything, like you see in Whole Foods. Not dissimilar entirely for these multi-state operators. Those I think are going to continue to have a lot of value, if done really well and if they scale. I think the small one-off operations I wouldn’t be as interested in.The second space that we’re really focused on is everything to do with biotech in this space and the ability for cannabis to be used for medicinal purposes, whether that’s biosynthesis or being able to actually create cannabis in a lab through things like yeast or algae. It’s way above my paygrade from a science understanding perspective, but we have somebody on the team that that’s their specialty, so they dive into those companies. So I think anything in biotech and that sector could be really interesting if you get the real plays. Then the third area is really well-executed brands who are able to scale nationally and hopefully globally. We’ve made a few of those bets in the brand space, but gosh, we have to see a lot.Explain to our audience exactly what you mean by brands in this context.That basically means who’s going to be the Coca-Cola, Pepsi, Frito-Lay, Blue Moon of cannabis. These are cannabis brands that will become household names, hopefully. We don’t really have any of those right now. I don’t really think you could argue that there is a nationally recognized cannabis brands I can’t tell you the amount of times I get pitched, individual small CBD brands or THC brands, and they might have really nice packaging or make you feel good – I mean, a lot of times it’s the same product. We’re all dealing with the same brands, so why is this one product going to break out as opposed to the other hundred that I get pitched? It’s very hard as an investor to know. Is it the people attached to it? It’s the difference between RC Cola and Coke. How do you know which is the one that’s going to stand outSometimes it’s very hard to tell whether it’s all hype or if there’s something real there. What would be your way to dig a little deeper?First, I would want to see real revenue. If we’re dealing with a company like Sublime, for instance, we’re talking about double-digit millions in revenue, so then you know that there’s something there. They’re able to operate, people are buying these companies.Then the second thing — I have two good friends that run a company called Windy Hill Brands, and they sold an alcohol company that I’m blanking on, but it was something Moonshine, to the guys who created Deep Eddy Vodka. They’re just brand geniuses. So one of the things is having people in your corner who understand this space.The most important part there is also their ability to distribute. I’ve made mistakes before in investing in brands – not at Cresco, but when I was investing at different venture funds. There was a brand that I loved and I wanted this product to exist in the world, but I realized that the management team didn’t have the distribution chops. So they weren’t able to get it on the shelves of Whole Foods, for instance, or CVS or whatever the case may be – and they didn’t have that crazy sales drive to do it.What you really need in the brand space is it’s all about your distribution, and can you actually get your product in the hands of the distributors, or can you get your product, through ecommerce, sold online in a big way? A lot of founders are pretty lazy about getting their sales out in that way, and they want to do some of the fun stuff. Nobody likes cold calling.Say you have no money to invest in cannabis. Not a dollar. I’ve totally been there; my dad didn’t get to go to college, so I remember having nothing to invest and worried about my debit card not going through.The one thing that you can do is look for sweat equity into these companies. That is basically where you start doing all the stuff we talked about – meeting people, reading about it, reaching out to them via email – and then you say, “I’m Codie,” for instance, and say I’m a graphic designer. “I could do some graphic design work for you. You don’t have to pay me. I’ll just do it for you, but how about I work for some percent ownership in the company, and you pay that to me over this time period?”Or you could say, “I, Jonathan, am really good at copywriting because I’m a journalist. Why don’t I help you write some of your copy for your website or to your clients, and in exchange for that you give me some equity?” So there are certainly ways to use your skillset as your capital. I would think about that. If you google “sweat equity,” you’ll get a million different ways to do it.That’s great advice. Is it helpful to make a list of what you have to offer? Like, are you a graphic designer, are you a good publicist? What are a lot of these companies looking for?I think everything. Totally all of them are looking for help from a marketing – the two things that almost every company needs immediately is sales, so they need somebody to go out and bring them more revenue, and they need help with marketing. They need, just like you said, people to pitch publishers, people to write copy. Social media somewhat, because social media is tricky in this space. But yeah, somebody who’s good with social media in a way that won’t get them banned from Instagram. Exactly. And you can always say, “What are things that you need to have done that are terrible, that you don’t want to do? I’ll do that.” You can also offer it more broadly if you don’t have a direct solution.I would say what they don’t need is like “I’m really good at strategy. Let me give you strategy.” Nope, we’re executing. We don’t have time for third-party strategy. So that’s probably not as useful. But introductions to capital, sales, marketing, graphic design, anything like that is really valuable to a startup. Would you recommend having a formal agreement with a company? What I would be concerned about is that – most people are good people, but there’s going to be some bad apples, and they’re going to take advantage of you and then sell and not give you anything. Should you have some sort of contract with them?Yeah. We all watched the Facebook story, right? How I’ve done it in the past, before I was a bigger investor, was I would have a little something drafted up. Again, you can find this online, like a sweat equity contract.But essentially I would have a little contract that basically says “Codie is going to provide the following services. For these services, she is going to be given X percent of equity,” for them to fill in – and it’ll be vested, which means I actually own it – “over a 6, 12, or 18 month period,” whatever period you choose.But what I would say upfront is, “Hey, why don’t I do this for you, work for you for the next 30 days for $free.99? Free, totally. I’ll do this work for you for 30 days. I believe in what you’re doing. This is the contract that I’d like to sign at the end of 30 days for me to keep helping you like this. Does that sound good?” Typically they’ll be good on that front. You might get burned once, but you’re going to learn a ton, and then you’ll learn who not to trust next time.I think in tandem with that, then you can actually start adding some cash components of it. Once they see your work and how useful you are, if you crush it for them, people don’t want that to stop. Entrepreneurs aren’t stupid. So if you’re doing good work and you had your little equity thing drawn up, you can ask for cash as well so you’re not slaving away for free for 5 years.  –shares Entrepreneur Staff Want to invest in the cannabis industry but barely have enough to buy your own weed? Cody Sanchez of Cresco Capital Partners has suggestions. Subscribe Now Editor in Chief of Green Entrepreneur Green Entrepreneur provides how-to guides, ideas and expert insights for entrepreneurs looking to start and grow a cannabis business.last_img read more

Marianne Williamson May Seem a Little Bananas but Shes Right to Focus

first_img Marianne Williamson Food 68shares Guest Writer Add to Queue 6 min read Cofounder and President of the Reducetarian Foundation Image credit: Bloomberg | Getty Images Opinions expressed by Entrepreneur contributors are their own. Brian Katemancenter_img Learn from renowned serial entrepreneur David Meltzer how to find your frequency in order to stand out from your competitors and build a brand that is authentic, lasting and impactful. Next Article Marianne Williamson May Seem a Little Bananas, but She’s Right to Focus on Food Issues Fireside Chat | July 25: Three Surprising Ways to Build Your Brand Williams’s contribution on the debate stage was small, but important. Fixing our broken healthcare system won’t be easy for politicians or entrepreneurs — but it would save millions of lives. July 15, 2019 Last month’s Democratic debate touched on a lot of important subjects. But not enough time was given to one of the most urgent problems in the U.S. today: our diets are killing us.Around 45 percent of deaths from heart disease, stroke and type 2 diabetes in 2012 could be because of a poor diet. About three-fourths of the population has a diet low in vegetables and fruit, while most are eating too much salt, saturated fat and sugar. Research has found that even small amounts of processed meats can increase the risk of death, from cancer and particularly heart disease.This public health disaster is really costing us. Rising rates of chronic disease accounted for an estimated $211 billion of the $314 billion increase in healthcare spending in the U.S. between 1987 and 2000. More recent research has found that one in five deaths between 1990 and 2017 were associated with poor diet.During the debate, presidential candidate Marianne Williamson mentioned the importance of going deeper than “superficial fixes.” “[W]e don’t have a health care system in the United States, we have a sickness care system in the United States,” she said. “We just wait until somebody gets sick and then we talk about who is going pay for the treatment and how they’re going to be treated.”She said we need to talk about why so many Americans have unnecessary chronic illnesses compared to other countries, and the influence government has on our diets, and subsequently, our health and wellbeing.“It gets back into not just Big Pharma, not just health insurance companies, but it has to do with chemical policies, it has to do with environmental policies, it has to do with food, it has to do with drug policies, and it has to do with environment policies,” Williamson said.Many voters think she doesn’t stand a chance of becoming president, but in this instance Williamson has stood out among her competitors because many policymakers don’t want to talk about this broader issue. It’s easy for them to think this battle is far longer than their time in office will be, that it’s too anti-business. But this wasn’t an off-the-cuff crusade for Williamson. On her website, she argues that:”Until America comes to terms with how much we have acquiesced to the many unhealthy practices that should be considered unlawful — but which are currently allowed in order to increase corporate profits — we will continue to have a less-than-meaningful discussion of how as a society we provide health care.”People aren’t eating poor diets by choice; the country’s food system is designed this way. Processed food and fast food (notorious for meat-sweet items) are often cheaper and more accessible, and many trade lobbyists are pushing onto the population the very foods we need to stop eating. Improving attitudes around diet and health and longevity is welcome, but we also need to recognize the huge role policymakers play in this, and hold them accountable. For example, Williamson said we should end agricultural subsidies for unhealthy foods, including high-fructose corn syrup (HFCS) and hydrogenated fats, and incentivize and subsidize those in industry and business making healthy food more available and affordable. Research has found that the rate of Type 2 diabetes is 20 percent higher in countries with higher availability of HFCS compared to countries that have less access to it.More and more scientists and entrepreneurs are acknowledging that we need to focus more on prevention and less on treatment, that it’s already too late when people seek help from their doctor to manage their weight. One hope is that AI and other futuristic technologies will be able to spot early markers of disease and help people prevent its onset through diet, exercise and lifestyle.Science and technology are also advancing the availability and quality of plant-based alternatives, which can play a role in helping people cut back on their meat intake. For example, in Beyond Meat’s R&D lab, an e-tongue “tastes” the Beyond Burger burgers for likeness to meat, and helps perfect the burger’s chewiness, and an e-nose isolates more than 1,000 animal and plant matter molecules. Whole plant-based foods would obviously be a healthier option, but meeting people where they are (like at the drive-thru at Carl’s Jr.) is arguably an important and realistic start.There are many complex and intertwining factors contributing to the soaring number of Americans with preventable diseases, and a wealth of legislation that could help: from education to food regulation, advertising standards to agriculture, what children are served in school, how scientists are funded and incentivized, the food patients are served in hospitals and the food deserts (and food swamps) preventing or disincentivizing populations from accessing fruit and vegetables.One major regulatory issue at the moment is labeling. States across the country are banning plant-based foods from using words such as “sausage” and “burger” to describe their products. Most recently, a ban in Mississippi prevents vegetarian and vegan foods from using such words. Many hope that legislators can push back on this, as there is no evidence for the main claim that such labeling confuses consumers, which courts have repeatedly affirmed.Michelle Obama’s efforts to tackle obesity and improve nutrition for children during her time as First Lady were commendable, despite criticisms for partnering with food giants. But now, we need much bolder policy change. Williams’s contribution on the debate stage was small, but important. Fixing our broken healthcare system won’t be easy for politicians or entrepreneurs — but it would save millions of lives. Given all that is at stake, let’s hope other candidates take a cue from Williams and raise food issues in the second Democratic debate. Enroll Now for $5last_img read more