Man Utd chief Woodward: Solskjaer job secureby Paul Vegas7 days agoSend to a friendShare the loveEd Woodward says Ole Gunnar Solskjaer will remain Manchester United manager no matter what happens against Liverpool on Sunday.Supporters are growing restless after United’s spluttering start which sees them in 12th with nine points from eight games.But Woodward insists the club have a long-term plan that includes Solskjaer at the helm.”Ole has also instilled the discipline back into an environment where we may have lacked it in recent years,” said Woodward in an address to staff at Old Trafford. “He is building a squad that respects the club’s history, in which players work hard and respect their team-mates.”No one is bigger than the club. The changes we saw over the summer have resulted in a very young squad. But it’s also a squad, with the players and the culture, that provides a base camp for us to build and grow from as we start our new journey.”He added: “Ole’s vision maps exactly to the core three football objectives we have: we must win trophies, we must play attacking football, and we must give youth its chance,” said Woodward.”The middle section of last season, after Ole’s arrival, feels most relevant to what we want to achieve and where we want to be, we saw a team playing fast, fluid football, with a clear representation of the style and philosophy the manager wants.” TagsTransfersAbout the authorPaul VegasShare the loveHave your say
The BCUC also received more than 70 letters of comment from members of the public and interested parties as well as three reports prepared by two independent consultants, shares the BCUC.The process also included four days of Oral Workshops for the Panel to ask Interveners questions, and for Interveners to ask questions on the independent reports.The Panel has recommended a one-month comment period on the Report to provide the Inquiry’s participants with an opportunity to submit additional evidence relevant to questions posed by the BC Government.To review the Panel’s detailed findings, refer to the Executive Summary or Final Report; CLICK HEREThe BCUC shares a final copy of the report has been provided to the Honourable Minister of Jobs, Trade and Technology. VANCOUVER, B.C. – The British Columbia Utilities Commission (BCUC) issued its Final Report with responses to questions posed by the Provincial Government and its key findings from its Inquiry into Gasoline and Diesel Prices in BC.Following the inquiry process, some of the Panel’s key findings include;There is a significant unexplained difference of approximately 13 cents per litre in wholesale gasoline prices between Southern BC and its Pacific Northwest cost comparator;The wholesale market for gasoline in BC is not truly competitive with high market concentration levels, high barriers to entry, and their ability to influence prices. Retail market prices can also be controlled by five refiner-marketers;There is no evidence to suggest that there is collusion among the retail operators nor is there evidence of cartel behaviour; andRegulation could potentially reduce the wholesale and/or retail margins to what is earned in comparable jurisdictions and reduce price volatility. However, further investigation should be done to determine if such an approach would be of benefit to British Columbian consumers.According to the BCUC, they established an independent, transparent and public inquiry process. The Panel considered evidence filed by 11 registered interveners including all major companies that have refining and retail business in BC.
Children who face adversities – such as parental separation – are more likely to suffer from gastrointestinal symptoms which may lead to mental health issues in later life, a study has found. The study, published in the journal Development and Psychopathology, found that gastrointestinal symptoms in children may have an impact on the brain and behaviour as they grow to maturity. “One common reason children show up at doctors’ offices is intestinal complaints,” said Nim Tottenham, a professor at Columbia University in the US. “Our findings indicate that gastrointestinal symptoms in young children could be a red flag to primary care physicians for future emotional health problems,” said Tottenham. Scientists have long noted the strong connection between the gut and brain. Previous research has demonstrated that a history of trauma or abuse has been reported in up to half of adults with irritable bowel syndrome (IBS), at a prevalence twice that of patients without IBS. “The role of trauma in increasing vulnerability to both gastrointestinal and mental health symptoms is well established in adults but rarely studied in childhood,” said Bridget Callaghan, a post-doctoral research fellow at Columbia. Animal studies have demonstrated that adversity-induced changes in the gut microbiome influence neurological development, but no human studies have done so. “Our study is among the first to link disruption of a child’s gastrointestinal microbiome triggered by early-life adversity with brain activity in regions associated with emotional health.” The researchers focused on development in children who experienced extreme psychosocial deprivation due to institutional care before international adoption. Separation of a child from a parent is known to be a powerful predictor of mental health issues in humans. That experience, when modelled in rodents, induces fear and anxiety, hinders neurodevelopment and alters microbial communities across the lifespan. The researchers drew upon data from 115 children adopted from orphanages or foster care on or before approximately they were two years old, and from 229 children raised by a biological caregiver. The children with past caregiving disruptions showed higher levels of symptoms that included stomach aches, constipation, vomiting and nausea. From that sample of adoptees, the researchers then selected eight participants, ages seven to 13, from the adversity exposed group and another eight who’d been in the group raised by their biological parents. The children with a history of early caregiving disruptions had distinctly different gut microbiomes from those raised with biological caregivers from birth. Brain scans of all the children also showed that brain activity patterns were correlated with certain bacteria. “It is too early to say anything conclusive, but our study indicates that adversity-associated changes in the gut microbiome are related to brain function, including differences in the regions of the brain associated with emotional processing,” said Tottenham.
New Delhi: The Congress Saturday hit out at the Modi government over Election Commissioner Ashok Lavasa recusing himself from EC meetings to discuss poll code violations, saying erosion of institutional integrity is the hallmark of the present dispensation. Congress’ chief spokesperson Randeep Surjewala cited a media report which claimed Lavasa, who disagreed with the poll panel’s decisions to clear Prime Minister Narendra Modi and BJP president Amit Shah of charges of violating the Model Code of Conduct (MCC), has since May 4 recused himself from all meetings to discuss MCC issues. Lavasa has reportedly insisted that he will do so only after dissent notes and minority decisions are included in the orders of the commission. “The Election Commission or Election Omission! Another Dark Day for Democracy!” Surjewala tweeted, tagging the media report. “Sh Ashok Lavasa, Member CEC, who dissented on multiple occasions when EC was busy giving clean chits to Modi-Shah duo, opts out of EC as the ECI even refuse to record dissent notes,” he said. Erosion of institutional integrity is the hallmark of the Modi government, Surjewala alleged. “SC Judges going public, RBI Governor’s resigning, CBI Director getting removed, CVC giving vacuous reports, Now dividing Election Commission!” the Congress leader said in another tweet. Will EC save the embarrassment by recording Lavasa’s dissent notes, he asked.
NAIROBI- At least four people were killed Saturday evening and 36 injured in an explosion on a minibus in Kenyan capital Nairobi.“A group of assailants threw a grenade into a bus with 32 seats,” the interior ministry said on its Twitter account.Police said the 36 injured were admitted to nearby hospitals with multiple injuries following the incident. The death toll is expected to rise due to the nature of injuries.No group has yet claimed responsibility for the attack.
Digital publishing consultancy Mequoda Group has released the results of its third Digital Magazine Market Study. This year, the firm tripled its sample size to 3,642 U.S. adults and backed off the tablet-specific demo they used for the previous studies, which negates year-over-year comparisons, but there are still more than a few highlights. Interestingly, that metric almost flips when Mequoda asked about print magazine readership. About 70 percent of respondents said they read an average of 2.91 print issues in the last 30 days while 30 percent did not read a print magazine at all. Either publishers are de-emphasizing monetization of subscriptions and single copy sales or most consumers simply aren’t buying. The study notes that 58 percent of respondents spent no money on digital magazine single copies or subscriptions in the last 12 months, and of those that did, they averaged $17.20. General advertising was a tick worse: Six percent said very important, 9 percent thought it was important, 21 percent said slightly important and 45 percent deemed it not important. Meanwhile, digital magazines don’t stand out as a singular preference when readers consider how they prefer to access magazine content. Yet, they’re holding their own against the print edition and web edition. Each format captured about a third of responses. Even so, advertising may not be viewed by readers as being part of a digital magazine’s functionality, but those low numbers indicate that readers are not seeing the value of advertising as part of a digital magazine experience. Those may be harder to deliver, if at all, in basic PDF versions of a magazine, but beyond those two, responses on other more dynamic content features become more fractured. Only 10 percent of respondents say embedded video is very important and 22 percent say it’s not important, for example. As for functionality, 79 percent of respondents say readable text is very important, while 56 percent say scrollable text is very important. Nevertheless, Mequoda notes that readable and scrollable text are features common in native and responsive web versions of digital magazines, which point to a reader preference for those formats. Advertising is way down on the functionality list, unfortunately. Nine percent said relevant advertising is ‘”very important” and 12 percent said it’s “important.” Thirty-seven percent said it’s “not important” and 17 percent said “slightly important.” Respondents are fairly active readers of digital magazines, but not overly so. According to the survey, about 63 percent had not read a digital magazine in the last 30 days. The remaining 37 percent read an average of 2.37 issues during that period, however. For the full study, including digital magazine best practices, click here.
[Representational Image]ReutersIBM investors from India earned over 800 patents — the second highest contributor to the company’s global record of 9,100 patents in the US in 2018 — with nearly half in the fields of Artificial Intelligence (AI), Cloud computing, cybersecurity, Blockchain and Quantum Computing.One of the patents filed from India went to IBM inventors Shivali Agarwal, Gaargi B Dasgupta, Shripad J Nadgowda and Tapan K Nayak, the company said in a statement on Tuesday.They developed an AI-based approach for structured representation and classification of noisy and unstructured data in tickets used in service delivery.Ticket analysis helps create problem diagnostics, prediction of outages and prevention of issues in service delivery, for example for help desks.”IBM is committed to leading the way on the technologies that change the way the world works – and solving problems many people have not even thought of yet,” said Ginni Rometty, IBM Chairman, President and CEO.Among more than 1,600 AI patents included “Project Debater” that, with the use of Machine Learning, can debate humans on complex topics — identifying evidence such as relevant text segments in unstructured text data, which supports or opposes a claim or topic under consideration.IBM inventors received more than 2,000 Cloud computing and over 1,600 AI patents.The new patents were granted to a diverse group of more than 8,500 IBM inventors in 47 US states and 48 countries.
We all want our kids and grandkids to grow up happier and healthier than we did. Instead, today’s children are the first generation of young Americans to face the prospect of living their entire lives in poorer health and dying younger than previous generations.The reason is no mystery. Too many of our children—one in three, according to studies—are overweight.The childhood obesity epidemic is having a devastating effect on too many families. Obese and overweight children are sick more often. They too often endure prejudice and bullying at school, leaving them embarrassed and depressed. They miss more school. When they grow up, they have more difficulty leading productive work lives. And they are more likely to suffer from chronic illnesses directly linked to obesity, such as diabetes and heart disease.All of society pays a stiff price for childhood obesity. Twenty percent of the United States’ total expenditures on health care can be linked to conditions associated with obesity. Obesity costs our society more than smoking or drinking.But there is reason for hope.Parents, educators, business leaders, government officials, health care professionals, and nonprofits have launched remarkable initiatives to end this epidemic. The Robert Wood Johnson Foundation has been a leader in these efforts, ever since its dramatic $500 million initiative in 2007 to reverse trends in childhood obesity. And there are signs that we are already creating a brighter future for our children.Parents are getting out and doing things with their kids—hiking, jogging, cycling, swimming, throwing a ball or Frisbee around—and both parents and kids find themselves feeling better. Schools are offering healthy lunch choices, and making good food, including breakfast, available for students who might otherwise be able to afford only junk food, or no food at all. Cities and states are requiring fast-food outlets to post nutrition information. Large retail chains are building fresh-food grocery stores that represent oases of healthy nutrition in “food deserts.” Hospitals and clinics are emphasizing preventive care programs. Foundations such as RWJF, with its efforts to build a Culture of Health, are promoting innovative pilot programs and partnerships. All these efforts, taken together, are truly making a difference.But there’s no question that we have a long way to go. That’s why RWJF is pledging another $500 million over the next 10 years to expand efforts to ensure that all children in the United States―no matter who they are or where they live―can grow up at a healthy weight.Senator Bill Frist, MDWhat can you do? Take a kid bowling, or for a hike. Suggest alternatives to fried foods at the next covered-dish supper held at your church. Write your elected representatives expressing your support for programs to fight childhood obesity. Present a petition to the school board asking that physical education be reinstated or expanded, and that unhealthy snacks and drinks be removed. Ask the city council to ensure that all kids and families have access to safe parks and playgrounds. Donate money or volunteer your time to programs fighting childhood obesity. Buy and serve healthy foods for yourself and your family, and do your best to let everyone in the food chain know—from the local grocery manager to the big brand-name food companies to the farmer at the local greenmarket—that you want healthy, fresh food.It’s been shown time and again, all across the country: If we make healthy food and exercise options easy and affordable, those are the choices that most families will make for their children. Please do your part to help America’s kids. Here at the Foundation, we’ll be supporting you all the way.Bill Frist, a heart surgeon, is a former U.S. senator (R-Tenn.) who has long been involved in promoting good health across America. He is a member of the Board of Trustees of the Robert Wood Johnson Foundation.
Citation: Managing complexity: Novel protein folding tool vastly simplifies understanding how sequence encodes structure (2016, November 29) retrieved 18 August 2019 from https://phys.org/news/2016-11-complexity-protein-tool-vastly-sequence.html (Phys.org)—Protein folding is the process by which a polypeptide (a linear organic polymer chain consisting of many amino acid residues, or monomers) transforms from a random coil into the 3D conformation in which it can perform its biological function. Since different proteins fold into a range of very different shapes, the Protein Data Bank (PDB) – a database archive comprising experimentally-determined three-dimensional structures of large biological molecules, including numerous protein conformations – can be disarmingly complex. This is problematic because that space is fundamental to understanding how sequence encodes structure. Recently, however, scientists at Dartmouth College deconstructed the universe of known protein structures into reusable building blocks that they term tertiary structural motifs, or TERMs. (Structural motifs are compact blocks of a 3D protein structure.) They found that 50% of PDB protein conformations were described – at sub-Angstrom resolution – by a surprisingly small group of roughly 600 TERMs. Moreover, TERMs allowed them to discern sequence–structure relationships. The researchers state that these results can be used for protein structure prediction, protein design and other applications. In addition, some 600 TERMs describe 50% of the known protein structural universe at sub-Angstrom resolution. “This refers to the level of degeneracy we discovered in the protein structure space.” That only ~600 TERMs are required to describe half of all residues and inter-residue contacts in known protein structures suggests that at the local structural level, there just are not that many structural patterns that naturally emerge. There are, of course, a large number of more rare geometries, and full coverage of the protein structural universe requires tens or even hundreds of thousands of TERMs – but nevertheless, the majority of protein structure does appear to be quite degenerate at the local level.”As to the specific implications of their study for protein structure prediction, protein design, and other applications, Grigoryan points out that the major implication for protein design and structure prediction is the novel means of mining for sequence-structure relationships. “Statistical potentials, derived from known protein structures, have been employed for decades in both of these applications. However, such potentials typically describe the statistics associated with isolated simplistic structural features, like dihedral angles, individual interatomic or interresidue distances, or burial environments. However, TERMs offer the potential to describe sequence statistics in the context of holistic structural environments, which would be much more useful for both design and prediction.” Specifically, he explains, in design, this would allow for a better understanding of what sequences would or would not form the target structure; for prediction, it would help drive structural sampling towards structures whose TERMs are most consistent with the modeled structure. “A potential limitation is the amount of available data, because not all TERMs have sufficient known instances to synthesize accurate sequence models,” he acknowledges. “However, the early results shown in our paper, as well as some unpublished results in our lab, point to the fact that TERM-based statistics are already providing non-trivial insights that in many cases, other methods are unable to easily capture – and this is only going to get better as the amount of structural data continues to accumulate.”When asked about the implications of their work for synthetic genomics and synthetic proteomics, Grigoryan said “It’s a good question. I can certainly see a future in which a truly robust method for computational protein design serves as a key element in synthetic genomics and proteomics applications. I’d say that in terms of our current design techniques, we’re not quite there today – but our goal with TERM-based and other developments – as well as the general goal of our field – is certainly to keep improving the robustness of our methods, so that one day, we can offer them as black-box solutions to folks in other disciplines, whether that be materials science, biomedicine, or synthetic biology.”Moving forward, Grigoryan says that the team is focused on extending the capabilities of their TERM-based techniques to both protein design and structure prediction. “We’re also very interested in introducing ensemble-based modeling approaches into protein design: Since protein structural states are really conformational ensembles, the language of statistical mechanics is most appropriate for describing their behavior. Therefore, we’re pursuing methods for introducing statistical mechanics-based calculations towards improving the accuracy and robustness of protein design methods.”In addition to protein design and structure prediction, Grigoryan sees their study as having strong implications for our fundamental understanding of protein structure in general. “I think the new look at the protein structural universe our study offers can help not only with modeling and designing proteins, but it can also help with teaching about protein structure. The ideas of modularity and representation of standard motifs,” he concludes, “have already made their way into my own teaching here at Dartmouth.” Fig. 1. Discovering TERMs that optimally describe the protein structural universe. (A) A candidate motif is defined around each residue in the database, structural matches (from within the database) to each motif are identified using MASTER (58), and these matches are used in defining the coverage of every motif. Next, the set cover problem is solved to find the minimal set of motifs that jointly cover the structural universe. (B) Coverage of the universe as a function of the number of TERMs, in the order discovered by the greedy algorithm (inset uses logarithmic scale along the x axis). Mackenzie CO, Zhou J, Grigoryan G (2016} Tertiary alphabet for the observable protein structural universe. Proc Natl Acad Sci USA 113(47):E7438-E7447. Fig. 2. Universal TERMs. (A) Top 24 TERMs ranked by the number of elements covered in the set cover procedure; jointly these cover roughly a third of the universe elements. (B) A diverse selection of high-priority TERMs that span from one- to five-segment motifs, shown in the first to fifth columns, respectively. Shown in each column are representatives from the three most common secondary-structure classes for the given number of segments (SI Appendix, SI Methods). In both A and B, each TERM is represented with ten randomly chosen matches along with its centroid. The text underneath each TERM is formatted as follows: r; n (s/c) where r is the rank of the TERM in the set cover (lower rank corresponds to higher priority), n is the number of unique matches, s is the total fraction of universe elements covered by the TERM, and c is the marginal fraction of the universe elements covered by the TERM (i.e., fractional coverage of those elements not already covered by preceding TERMs in the set cover). Mackenzie CO, Zhou J, Grigoryan G (2016} Tertiary alphabet for the observable protein structural universe. Proc Natl Acad Sci USA 113(47):E7438-E7447. Grigoryan adds that by using residues and contacts rather than an a priori structural alphabet, defining the motif candidates was much easier. “It seemed particularly natural to define one candidate motif for every residue in the structural database,” he notes, “such that the motif would capture the residue and all of its contacts – that is, the motif would describe that residue’s local structural environment.” More information: Tertiary alphabet for the observable protein structural universe, PNAS November 3, 2016, Published online before print, doi:10.1073/pnas.1607178113 Researchers find possible universal code of protein structure A key finding discussed in the paper was that universal TERMs provide an effective mapping between sequence and structure. “Because universal TERMs recur many times in unrelated proteins,” Grigoryan tells Phys.org, “compiling the list of occurrences of each TERM allows us to start gleaning sequence rules that may underlie each of these structural motifs. The question was whether these sequence rules reflected fundamental determinants of structure, or simply noise from a limited structural database potentially biased by arbitrary evolutionary choices or the selection of proteins whose structures have been solved.” The team resolved this through a series of experiments in which they demonstrated that a significant component of the sequence statistics emerging from TERM matches does likely emerge from fundamental sequence-structure relationships.In effect, the natural utilization of TERMs provides a means of uncovering sequence–structure relationships. “Let’s say a given TERM is consistent of a two-strand beta sheet interacting with an alpha helix at a particular characteristic crossing angle and distance,” Grigoryan illustrates. “If we happen to have, for example, 600 instances of this motif from unrelated proteins, we essentially have 600 different examples of nature having made this structure with different amino-acid sequences. We can then use these 600 sequences to begin to understand what sequence features may be required or preferred to form such a structure – and we can do this for any TERM with sufficiently high usage in nature.”It turns out that by using this approach systematically for all TERMs contained in a given protein backbone structure, sequence variability predicted from TERM data agrees closely with evolutionary variation. “We can deduce a statistical model of what sorts of sequences would be likely to fold to that structure,” he explains. “If we then ask this model to produce a whole bunch of such sequences, we find that the emergent sequence variability is often in close agreement to the evolutionary variability observe for the corresponding protein.” © 2016 Phys.org This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Prof. Gevorg Grigoryan discussed the paper that he and his co-authors published in Proceedings of the National Academy of Science of the United States of America. One of the primary challenges in their study was decomposing the set of known protein structures into standard reusable tertiary structural motifs. “The main challenge here was probably knowing where to begin,” Grigoryan tells Phys.org. “Our overarching goal was to describe, in his words, an alphabet of protein structure.” However, he points out that – unlike with text – the researchers were not able to visually determine where one structural unit (metaphorically a letter) began and another ended. “The number of ways in which we can potentially partition protein structure is extremely large, and so the task of finding a good decomposition seemed overwhelming.”The scientists addressed this problem by not defining a priori what the letters of the structural alphabet should be, but rather defining the task that these letters should accomplish – that is, describing the set of all residues and residue pair contacts observed in known protein structures. Next, they selected the smallest set of reusable building blocks they’re named tertiary structural motifs, or TERMs, that would achieve this goal.Another hurdle in determining the set of universal TERMs that capture all structure in the PDB was the difficult task of sifting through 13 million candidate TERMs, and describing which residues and contacts in known protein structures they individually explained. “Our previously-developed, efficient structure search algorithm MASTER helped us resolve this – but the total amount of computational time involved was still quite large, so we had to make use of a computer cluster.” A computer cluster is a single logical unit comprising multiple networked-linked computers. Explore further Fig. 5. An EF-hand TERM. (A) The 31 nonredundant EF hand-containing instances of the TERM (gray) with adjacent structure (green). Calcium atoms from TERM instances are shown as yellow spheres. (B) TERM instances alone with calcium-contacting side chains shown with sticks. (C) Variability among TERM instances. Four instances are shown in gray: two EF-hand examples with varying loop geometries (surrounding structure in green) and two non–EF-hand instances (from PDB ID codes 3HNO and 1CB7, surrounding structure in cyan), including one with TERM segments belonging to different chains. (D) Sequence logo of nonredundant EF hand-containing matches of the TERM. Position 18 corresponds to the canonical EF hand loop position 1 (61). Mackenzie CO, Zhou J, Grigoryan G (2016} Tertiary alphabet for the observable protein structural universe. Proc Natl Acad Sci USA 113(47):E7438-E7447. Journal information: Proceedings of the National Academy of Sciences
Kolkata: An elderly couple from Malda was beaten up by their family members over property dispute.The incident took place at Kashimpur village of Chanchal in Malda on Tuesday morning. The couple has been undergoing treatment at Malda Medical College and Hospital. According to the hospital sources, both of them received head injuries in the incident. It was learnt that a quarrel broke out between three brothers over possession of a plot of 16 cottah. The victim’s younger brothers went to the spot in the morning to capture the disputed piece of land while the eldest brother and his wife opposed them. It was alleged that the two brothers with the help of some of their associates attacked the elderly couple. They were hit on head with a stick. The locals rescued the injured couple and took them to the hospital. The villagers told the police that there was an on-going family quarrel for the past few months. This time it turned ugly. A specific complaint has been lodged at Chanchal police station on the basis of which police have started a probe. Two accused have been at large since the incident took place. The family members of the victims are being interrogated in this regard.